Výsledky vyhledávání - "mouse double minute 2 homolog (MDM2)"

Akademický článek

Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Autor: Pei Pei, Xiyue cheng, Juan Yu, Jinying Shen, Xue Li, Jianxin Wu, Shan Wang, Ting Zhang

Publikováno v: Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-19 (2019)

Abstract Background Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases the risk of NTDs, th

Externí odkaz: https://doaj.org/article/4bf258fef3704c5cafe4ddcfcc58edee

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Akademický článek

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Akademický článek

Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Autor: Aiting Wang, Mengdi Yang, Rui Liang, Fangming Zhu, Fuxiang Zhu, Xinnan Liu, Yichao Han, Ruirong Lin, Xiaoxia Wang, Dan Li, Hecheng Li, Xiaojun Yuan, Hui Zhao, Bin Li

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Regulatory T cells (Treg cells) are essential for maintaining immune tolerance, and the dysfunction of Treg cells may cause autoimmune diseases and tumors. Forkhead box P3 (FOXP3) is the key transcription factor controlling Treg cell development and

Externí odkaz: https://doaj.org/article/6c7baed319ee4a789a50f36bd1a926d2

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Metallothionein 1M (MT1M) inhibits lung adenocarcinoma cell viability, migration, and expression of cell mobility-related proteins through MDM2/p53/MT1M signaling

Autor: Tie-Liang Ma, Wei Xu, Guo-Jun Jiang, Ming-Zhi Chen, Guo-Zhen Shi, Yong-Fei Tan

Publikováno v: Translational Cancer Research

Background Metallothionein 1M (MT1M) functions to regulate cell proliferation and cancer metastasis. This study assessed the effects of MT1M overexpression and mouse double minute 2 homolog (MDM2) knockdown on the regulation of non-small cell lung ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2788eb5effe97796ac36dc4acaff8bd2
http://europepmc.org/articles/PMC8798298

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Gain-of-Function Mutant TP53 R248Q Overexpressed in Epithelial Ovarian Carcinoma Alters AKT-Dependent Regulation of Intercellular Trafficking in Responses to EGFR/MDM2 Inhibitor

Autor: Zih-Yin Lai, Kai-Yun Tsai, Yung-Jen Chuang, Shing-Jyh Chang

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 8784, p 8784 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 16

As the most common gene mutation found in cancers, p53 mutations are detected in up to 96% of high-grade serous ovarian carcinoma (HGSOC). Meanwhile, mutant p53 overexpression is known to drive oncogenic phenotypes in cancer patients and to sustain t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73632f9419ca10c2e6450ba97d7c94a8
https://www.mdpi.com/1422-0067/22/16/8784

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Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function

Autor: Dan Li, Hecheng Li, Xinnan Liu, Fangming Zhu, Aiting Wang, Bin Li, Xiaoxia Wang, Xiaojun Yuan, Fuxiang Zhu, Yichao Han, Rui Liang, Mengdi Yang, Hui Zhao, Ruirong Lin

Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2f67f74ec3456aef0146008c28ceaa
https://doi.org/10.3389/fimmu.2020.01087

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Akademický článek

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Folate deficiency induced H2A ubiquitination to lead to downregulated expression of genes involved in neural tube defects

Autor: Jianxin Wu, Shan Wang, Juan Yu, Xue Li, Xiyue cheng, Ting Zhang, Pei Pei, Jinying Shen

Publikováno v: Epigenetics & Chromatin
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-19 (2019)

Background Neural tube defects (NTDs) are common congenital malformations resulting in failure of the neural tube closure during early embryonic development. Although it is known that maternal folate deficiency increases the risk of NTDs, the mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d78416e90452879c94c963966d63c82
https://doi.org/10.1186/s13072-019-0312-7

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