Zobrazeno 1 - 10
of 2 903
pro vyhledávání: '"motor fluctuations"'
Autor:
Mohammad Amin Karimi, Alireza Ghajari, Reza Khademi, Mohammad Hossein Etemadi, Narges Safar Firouz, Behnaz Mohammadvand, Kimia Janeshin, Afra Darvishi, Shafagh Asgarzadeh, Sayedeh-Fatemeh Sadat-Madani, Mohammad Abbasalizadeh, Zahra Jafari Shendi, Ata Akhtari Kohnehshahri, Niloofar Deravi, Seyed Amirhossein Mazhari, Mahsa Aziz, Matin Bidares, Mohaddeseh Belbasi, Mahdyieh Naziri, Hossein Ashkpour Motlagh
Publikováno v:
IBRO Neuroscience Reports, Vol 17, Iss , Pp 207-219 (2024)
Background: Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by dopamine depletion and severe motor impairments. Preladenant, an adenosine A2 receptor antagonist, is an investigational treatment for PD. This systematic r
Externí odkaz:
https://doaj.org/article/9327aa8a9c8b4c3c9183f771774b0db9
Autor:
Fabrizio Stocchi, Paolo Barone, Roberto Ceravolo, Maria Francesca De Pandis, Leonardo Lopiano, Nicola Modugno, Alessandro Padovani, Manuela Pilleri, Alessandro Tessitore, Mario Zappia
Publikováno v:
Annals of Medicine, Vol 56, Iss 1 (2024)
AbstractBackground Oral levodopa remains the mainstay of treatment for Parkinson’s disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients. There is a paucity
Externí odkaz:
https://doaj.org/article/702afcd4a74a4f599a04d871df252cc2
Autor:
Kanako Asai, Sayo Kawahara, Emi Shirahata, Kimihiro Iwasaki, Hikoichiro Nakai, Yuta Kajiyama, Seira Taniguchi, Lindun Ge, Keita Kakuda, Yasuyoshi Kimura, Tadashi Miyahara, Hiroki R. Ueda, Kensuke Ikenaka, Hideki Mochizuki
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundPaper symptom diaries are a common tool for assessing motor fluctuations in Parkinson’s disease (PD) patients, but there are concerns about inaccuracies in the assessment of motor fluctuation due to recall bias and poor compliance. We, th
Externí odkaz:
https://doaj.org/article/d17aeb37b8a145489df4cc75245d4a96
Autor:
Nicola L. Brice, Mark Carlton, David H. Margolin, Martin Bexon, Kim L. Matthews, Lee A. Dawson, Aaron L. Ellenbogen, C. Warren Olanow, Jordan Dubow, Karl Kieburtz
Publikováno v:
EClinicalMedicine, Vol 77, Iss , Pp 102882- (2024)
Summary: Background: CVN424 is a GPR6 inverse agonist that provides selective pharmacological control of the indirect striatopallidal pathway. We assessed the safety and efficacy of CVN424 as an adjunctive treatment to levodopa for reducing OFF-time
Externí odkaz:
https://doaj.org/article/03ffbbb6c9d240da9bd6c36037040312
Akademický článek
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Autor:
Jason Aldred, Eric Freire-Alvarez, Alexander V. Amelin, Angelo Antonini, Bruno Bergmans, Filip Bergquist, Manon Bouchard, Kumar Budur, Camille Carroll, K. Ray Chaudhuri, Susan R. Criswell, Erik H. Danielsen, Florin Gandor, Jia Jia, Thomas E. Kimber, Hideki Mochizuki, Weining Z. Robieson, Amy M. Spiegel, David G. Standaert, Saritha Talapala, Maurizio F. Facheris, Victor S. C. Fung
Publikováno v:
Neurology and Therapy, Vol 12, Iss 6, Pp 1937-1958 (2023)
Abstract Introduction Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment of Parkinson’s disease (PD), is administered as a 24-hour/day continuous subcutaneous infusion (CSCI) with a single infus
Externí odkaz:
https://doaj.org/article/3c28527413ce4845845ba7b0a3dbeb25
Autor:
Victor S.C. Fung, Jason Aldred, Martha P. Arroyo, Filip Bergquist, Agnita J.W. Boon, Manon Bouchard, Sarah Bray, Sara Dhanani, Maurizio F. Facheris, Nahome Fisseha, Eric Freire-Alvarez, Robert A. Hauser, Anna Jeong, Jia Jia, Pavnit Kukreja, Michael J. Soileau, Amy M. Spiegel, Saritha Talapala, Arjun Tarakad, Enrique Urrea-Mendoza, Jorge Zamudio, Rajesh Pahwa
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 10, Iss , Pp 100239- (2024)
Background: As Parkinson's disease (PD) advances, management is challenged by an increasingly variable and inconsistent response to oral dopaminergic therapy, requiring special considerations by the provider. Continuous 24 h/day subcutaneous infusion
Externí odkaz:
https://doaj.org/article/ee4b4d82effb4c59b7e2610de99a7111
Publikováno v:
Neurology and Therapy, Vol 12, Iss 2, Pp 391-424 (2023)
Abstract Motor fluctuations (MF) are deemed by patients with Parkinson's disease (PD) as the most troublesome disease feature resulting from the increasing impairment in responsiveness to dopaminergic drug treatments. MF are characterized by the loss
Externí odkaz:
https://doaj.org/article/e4d8fc35da58426baa3f251d2cc1d79d
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionEffective management and therapies for the motor complications of Parkinson’s disease (PD) require appropriate clinical evaluation. The Parkinson’s KinetiGraph™ (PKG) is a wearable biosensor system that can record the motion charact
Externí odkaz:
https://doaj.org/article/2c60b7290221461189b9787c7391708a
Autor:
Szabolcs Szatmári, József Attila Szász, Károly Orbán-Kis, Beáta Baróti, Simona Bataga, Marius Ciorba, Előd Ernő Nagy, Radu Mircea Neagoe, István Mihály, Péter Zsombor Szász, Krisztina Kelemen, Attila Frigy, Mónika Szilveszter, Viorelia Adelina Constantin
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 453 (2024)
Levodopa–entacapone–carbidopa intestinal gel infusion is a relatively new treatment option for advanced Parkinson’s disease. We aimed to describe and analyze the characteristics of de novo levodopa–entacapone–carbidopa intestinal gel therap
Externí odkaz:
https://doaj.org/article/14b4fec2497743729dc9ba6599adfd6b