Zobrazeno 1 - 10
of 8 294
pro vyhledávání: '"motoneuron"'
Autor:
Fabio Sarto, Martino V. Franchi, Jamie S. McPhee, Daniel W. Stashuk, Matteo Paganini, Elena Monti, Maira Rossi, Giuseppe Sirago, Sandra Zampieri, Evgeniia S. Motanova, Giacomo Valli, Tatiana Moro, Antonio Paoli, Roberto Bottinelli, Maria A. Pellegrino, Giuseppe De Vito, Helen M. Blau, Marco V. Narici
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1797-1810 (2024)
Abstract Background Degeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age‐related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensivel
Externí odkaz:
https://doaj.org/article/fd1d5ef2771c4359bc285ecaafe7b482
Autor:
A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, M. P. Topuzova, T. M. Alekseeva
Publikováno v:
Нервно-мышечные болезни, Vol 14, Iss 3, Pp 72-80 (2024)
In the last decade, pathogenetic methods for the treatment of spinal muscular atrophy 5q have been developed. These include increased expression of the SMN2 gene, correction of SMN2 splicing, or reexpression of the SMN1 gene. Despite the comprehensio
Externí odkaz:
https://doaj.org/article/db80cbb022b4417f910964091c830ea3
Autor:
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. In this study, we evaluated whether intranasal delivery of mesenchymal stem cell–de
Externí odkaz:
https://doaj.org/article/55635ea822c147fb8e471bec3d7a360e
Autor:
Matthieu K Chardon, Y Curtis Wang, Marta Garcia, Emre Besler, J Andrew Beauchamp, Michael D'Mello, Randall K Powers, Charles J Heckman
Publikováno v:
eLife, Vol 12 (2024)
In this study, we develop new reverse engineering (RE) techniques to identify the organization of the synaptic inputs generating firing patterns of populations of neurons. We tested these techniques in silico to allow rigorous evaluation of their eff
Externí odkaz:
https://doaj.org/article/dca4fd6afd794d27ba7331811bbcf343
Autor:
Wenyue Guan, Ziyan Nie, Anne Laurençon, Mathilde Bouchet, Christophe Godin, Chérif Kabir, Aurelien Darnas, Jonathan Enriquez
Publikováno v:
eLife, Vol 12 (2024)
Neuronal stem cells generate a limited and consistent number of neuronal progenies, each possessing distinct morphologies and functions, which are crucial for optimal brain function. Our study focused on a neuroblast (NB) lineage in Drosophila known
Externí odkaz:
https://doaj.org/article/913c3bada36c4a8dba08ea49c5cd6f20
Autor:
Gabriel Barrios, Anne Olechowski-Bessaguet, Mathilde Pain, Julien Bacqué-Cazenave, Laura Cardoit, Marie-Jeanne Cabirol, Didier Le Ray, François M. Lambert
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In all vertebrates, maintaining trunk posture primarily depends on descending commands originating from brainstem vestibulospinal nuclei. Despite being broadly outlined across species, the detailed anatomical and operational structure of these vestib
Externí odkaz:
https://doaj.org/article/04dcffecb1f24f94ae54ed4bf1ccdaeb
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 276, Iss , Pp 116327- (2024)
Roxithromycin (ROX), a commonly used macrolide antibiotic, is extensively employed in human medicine and livestock industries. Due to its structural stability and resistance to biological degradation, ROX persists as a resilient environmental contami
Externí odkaz:
https://doaj.org/article/67e38a42def94b59a0b1f1d23f6a051d
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5266 (2024)
The muscle contraction during voluntary movement is controlled by activities of alpha- and gamma-motoneurons (αMNs and γMNs, respectively). In spite of the recent advances in research on molecular markers that can distinguish between αMNs and γMN
Externí odkaz:
https://doaj.org/article/de888d61d4bb4a3fb48bd89f05b17fda
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106454- (2024)
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis. The RNA-binding protein hnRNP R interacts with different motoneuron disease-related proteins s
Externí odkaz:
https://doaj.org/article/d766e987d3874166a11bbf62be69a257