Zobrazeno 1 - 10
of 8 300
pro vyhledávání: '"motoneuron"'
Autor:
P. Lizandra Cortés, D. Poveda Verdú, A. Albert Férriz, N.C. Ñungo-Garzón, M.C. Domine, T. Sevilla-Mantecón, I. Pitarch-Castellano, J.F. Vázquez-Costa
Publikováno v:
Neurología, Vol 39, Iss 9, Pp 733-742 (2024)
Resumen: Introducción: La atrofia muscular espinal 5q (AME) es una enfermedad genética neurodegenerativa que afecta a las motoneuronas alfa produciendo debilidad progresiva. Actualmente se precisan nuevas herramientas que permitan medir y caracteri
Externí odkaz:
https://doaj.org/article/407b92b240634272883fde48f25f7def
Autor:
Oliver Hayman, Paul Ansdell, Luca Angius, Kevin Thomas, Lauren Horsbrough, Glyn Howatson, Dawson J. Kidgell, Jakob Škarabot, Stuart Goodall
Publikováno v:
Experimental Physiology, Vol 109, Iss 11, Pp 1896-1908 (2024)
Abstract Unaccustomed eccentric exercise (EE) is protective against muscle damage following a subsequent bout of similar exercise. One hypothesis suggests the existence of an alteration in motor unit (MU) behaviour during the second bout, which might
Externí odkaz:
https://doaj.org/article/45729b434d2f446681c43835871edfc7
Autor:
Pablo Martínez, Mónica Silva, Sebastián Abarzúa, María Florencia Tevy, Enrique Jaimovich, Martha Constantine-Paton, Fernando J. Bustos, Brigitte van Zundert
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-19 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-lin
Externí odkaz:
https://doaj.org/article/d3d643b2145c4f048ce0d7b5e781c070
Autor:
Fabio Sarto, Martino V. Franchi, Jamie S. McPhee, Daniel W. Stashuk, Matteo Paganini, Elena Monti, Maira Rossi, Giuseppe Sirago, Sandra Zampieri, Evgeniia S. Motanova, Giacomo Valli, Tatiana Moro, Antonio Paoli, Roberto Bottinelli, Maria A. Pellegrino, Giuseppe De Vito, Helen M. Blau, Marco V. Narici
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1797-1810 (2024)
Abstract Background Degeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age‐related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensivel
Externí odkaz:
https://doaj.org/article/fd1d5ef2771c4359bc285ecaafe7b482
Autor:
A. I. Vlasenko, V. D. Nazarov, S. V. Lapin, A. V. Mazing, E. A. Surkova, T. V. Blinova, M. P. Topuzova, T. M. Alekseeva
Publikováno v:
Нервно-мышечные болезни, Vol 14, Iss 3, Pp 72-80 (2024)
In the last decade, pathogenetic methods for the treatment of spinal muscular atrophy 5q have been developed. These include increased expression of the SMN2 gene, correction of SMN2 splicing, or reexpression of the SMN1 gene. Despite the comprehensio
Externí odkaz:
https://doaj.org/article/db80cbb022b4417f910964091c830ea3
Autor:
Jinrui Zhou, Fuxiang Li, Bin Jia, Zicong Wu, Zhonghai Huang, Meiting He, Huandi Weng, Kwok-Fai So, Wenrui Qu, Qing-Ling Fu, Libing Zhou
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. In this study, we evaluated whether intranasal delivery of mesenchymal stem cell–de
Externí odkaz:
https://doaj.org/article/55635ea822c147fb8e471bec3d7a360e
Autor:
Matthieu K Chardon, Y Curtis Wang, Marta Garcia, Emre Besler, J Andrew Beauchamp, Michael D'Mello, Randall K Powers, Charles J Heckman
Publikováno v:
eLife, Vol 12 (2024)
In this study, we develop new reverse engineering (RE) techniques to identify the organization of the synaptic inputs generating firing patterns of populations of neurons. We tested these techniques in silico to allow rigorous evaluation of their eff
Externí odkaz:
https://doaj.org/article/dca4fd6afd794d27ba7331811bbcf343
Autor:
Wenyue Guan, Ziyan Nie, Anne Laurençon, Mathilde Bouchet, Christophe Godin, Chérif Kabir, Aurelien Darnas, Jonathan Enriquez
Publikováno v:
eLife, Vol 12 (2024)
Neuronal stem cells generate a limited and consistent number of neuronal progenies, each possessing distinct morphologies and functions, which are crucial for optimal brain function. Our study focused on a neuroblast (NB) lineage in Drosophila known
Externí odkaz:
https://doaj.org/article/913c3bada36c4a8dba08ea49c5cd6f20
Autor:
Gabriel Barrios, Anne Olechowski-Bessaguet, Mathilde Pain, Julien Bacqué-Cazenave, Laura Cardoit, Marie-Jeanne Cabirol, Didier Le Ray, François M. Lambert
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
In all vertebrates, maintaining trunk posture primarily depends on descending commands originating from brainstem vestibulospinal nuclei. Despite being broadly outlined across species, the detailed anatomical and operational structure of these vestib
Externí odkaz:
https://doaj.org/article/04dcffecb1f24f94ae54ed4bf1ccdaeb