Zobrazeno 1 - 10
of 79
pro vyhledávání: '"morphological profiling"'
Autor:
Floriane Odje, David Meijer, Elena von Coburg, Justin J. J. van der Hooft, Sebastian Dunst, Marnix H. Medema, Andrea Volkamer
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
The cell painting (CP) assay has emerged as a potent imaging-based high-throughput phenotypic profiling (HTPP) tool that provides comprehensive input data for in silico prediction of compound activities and potential hazards in drug discovery and tox
Externí odkaz:
https://doaj.org/article/db08b0896cf645dfbf1580b3e2b0f380
Autor:
Connor J. Greatbatch, MBBS, Qinyi Lu, MD, PhD, Sandy Hung, PhD, Son N. Tran, PhD, Kristof Wing, MBBS, Helena Liang, MD, PhD, Xikun Han, PhD, Tiger Zhou, FRANZCO, PhD, Owen M. Siggs, MD, PhD, David A. Mackey, FRANZCO, MD, Guei-Sheung Liu, PhD, Anthony L. Cook, PhD, Joseph E. Powell, PhD, Jamie E. Craig, FRANZCO, DPhil, Stuart MacGregor, PhD, Alex W. Hewitt, FRANZCO, PhD
Publikováno v:
Ophthalmology Science, Vol 4, Iss 4, Pp 100504- (2024)
Purpose: Genome-wide association studies have recently uncovered many loci associated with variation in intraocular pressure (IOP). Artificial intelligence (AI) can be used to interrogate the effect of specific genetic knockouts on the morphology of
Externí odkaz:
https://doaj.org/article/abb1ee8966924ea990c570465f440c02
Autor:
Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Luca Greiner, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Christopher Squire, Daniel J. Foley, Slava Ziegler, Michael Grigalunas, Herbert Waldmann
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linke
Externí odkaz:
https://doaj.org/article/9073737db646428dab117fefc2793b21
Autor:
Rudmer J. Postma, Annelotte G.C. Broekhoven, Hein W. Verspaget, Hetty de Boer, Thomas Hankemeier, Minneke J. Coenraad, Vincent van Duinen, Anton Jan van Zonneveld
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 2, Pp 238-249 (2024)
Background and Aims: Endothelial cell (EC) dysfunction in response to circulating plasma factors is a known causal factor in many systemic diseases. However, no appropriate assay is available to investigate this causality ex vivo. In liver cirrhosis,
Externí odkaz:
https://doaj.org/article/742f63ba3443492ebb728d8cb78e9eb4
Autor:
Andi Alijagic, Oleksandr Kotlyar, Maria Larsson, Samira Salihovic, Alexander Hedbrant, Ulrika Eriksson, Patrik Karlsson, Alexander Persson, Nikolai Scherbak, Kim Färnlund, Magnus Engwall, Eva Särndahl
Publikováno v:
Environment International, Vol 183, Iss , Pp 108412- (2024)
Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing or additive manufacturing (AM). Powder-based AM technologies
Externí odkaz:
https://doaj.org/article/f8d25f1020a4471284e1b6306457ec2d
Publikováno v:
Molecular Systems Biology, Vol 18, Iss 11, Pp 1-23 (2022)
Abstract Spatial structure in biology, spanning molecular, organellular, cellular, tissue, and organismal scales, is encoded through a combination of genetic and epigenetic factors in individual cells. Microscopy remains the most direct approach to e
Externí odkaz:
https://doaj.org/article/d0dbc8fc7466427390ba183d21c1a17d
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Jonne Rietdijk, Marianna Tampere, Aleksandra Pettke, Polina Georgiev, Maris Lapins, Ulrika Warpman-Berglund, Ola Spjuth, Marjo-Riitta Puumalainen, Jordi Carreras-Puigvert
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background The emergence and continued global spread of the current COVID-19 pandemic has highlighted the need for methods to identify novel or repurposed therapeutic drugs in a fast and effective way. Despite the availability of methods for
Externí odkaz:
https://doaj.org/article/9068f8fd2df24d619691a2135b248fc7