Zobrazeno 1 - 10
of 658
pro vyhledávání: '"monomethyl auristatin E"'
Autor:
Xiaojie Chu, Seungmin Shin, Du-San Baek, Liyong Zhang, Alex Conard, Megan Shi, Ye-Jin Kim, Cynthia Adams, Maggie Hines, Xianglei Liu, Chuan Chen, Zehua Sun, Dontcho V. Jelev, John W. Mellors, Dimiter S. Dimitrov, Wei Li
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Prostate stem cell antigen (PSCA) is expressed in all stages of prostate cancer, including in advanced androgen-independent tumors and bone metastasis. PSCA may associate with prostate carcinogenesis and lineage plasticity in prostate cancer. PSCA is
Externí odkaz:
https://doaj.org/article/1f085d6811ce4dcda8bde14f50a5302f
Autor:
Jingyue Kang, Zongliang Zhang, Ruyuan Zhang, Meijun Zheng, Caiying Jiang, Hui Yang, Aiping Tong, Yan Zhang
Publikováno v:
MedComm – Oncology, Vol 3, Iss 2, Pp n/a-n/a (2024)
Abstract Malignant pleural mesothelioma (MPM) is a malignant tumor of the pulmonary pleural tissue for which there is a lack of effective targeted therapy. In this study, moderate to high V‐domain immunoglobulin T‐cell activation suppressor (VIST
Externí odkaz:
https://doaj.org/article/2da3a3df5a434fec95a29dc61720a1b3
Autor:
Shun Uchida, Satoshi Serada, Yuji Suzuki, Eiji Funajima, Kei Kitakami, Kazumasa Dobashi, Satomi Tamatani, Yuichi Sato, Takaaki Beppu, Kuniaki Ogasawara, Testuji Naka
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 50, Iss , Pp 100982- (2024)
Glioblastoma is the deadliest form of brain tumor. The presence of the blood–brain barrier (BBB) significantly hinders chemotherapy, necessitating the development of innovative treatment options for this tumor. This report presents the in vitro and
Externí odkaz:
https://doaj.org/article/937a68df2d134b64927973de614e8c9c
Autor:
Changqiang Xie, Yan Wang, Zhenzhen Cai, Jianghai Du, Zhengyu Chen, Junjie Wang, Xingzhou Peng
Publikováno v:
Journal of Innovative Optical Health Sciences, Vol 17, Iss 02 (2024)
Monomethyl auristatin E (MMAE) is a derivative of the marine peptide Dolastatin 10, which has therapeutic effects against various cancers according to its antimitotic activity in multiple clinical trials. The antibody drug conjugate (ADC) of MMAE is
Externí odkaz:
https://doaj.org/article/e11796a6ac30407488bf9a2a949eedef
Autor:
Marco Zambra, Ivan Ranđelović, Francesco Talarico, Adina Borbély, Laura Svajda, József Tóvári, Gábor Mező, Lizeth Bodero, Sveva Colombo, Federico Arrigoni, Elettra Fasola, Silvia Gazzola, Umberto Piarulli
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Antibody-Drug Conjugates (ADCs) and Small Molecule-Drug Conjugates (SMDCs) represent successful examples of targeted drug-delivery technologies for overcoming unwanted side effects of conventional chemotherapy in cancer treatment. In both strategies,
Externí odkaz:
https://doaj.org/article/8398d4cb126548328281d797762b4133
Akademický článek
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Autor:
Ayana Uchimura, Hajime Yasuda, Jun Ando, Yasunori Ota, Makoto Sasaki, Tomoiku Takaku, Yutaka Tsukune, Miyuki Tsutsui, Yoko Edahiro, Naoki Watanabe, Tomonori Ochiai, Norio Komatsu, Miki Ando
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 1, Pp 263-266 (2022)
Chemotherapy for hemodialysis (HD) patients is a challenging situation because HD patients are generally frail, and the pharmacokinetics and pharmacodynamics of most chemotherapeutics in HD patients are unknown. We report a classical Hodgkin lymphoma
Externí odkaz:
https://doaj.org/article/2360cfab3b874c888bf45da5c3e23ed0
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Nikolai Y. Zyk, Anastasiia S. Garanina, Ekaterina A. Plotnikova, Anton P. Ber, Ekaterina A. Nimenko, Natalia S. Dashkova, Anastasiia A. Uspenskaia, Radik R. Shafikov, Dmitry A. Skvortsov, Stanislav A. Petrov, Andrey A. Pankratov, Nikolai V. Zyk, Alexander G. Majouga, Elena K. Beloglazkina, Aleksei E. Machulkin
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11327 (2023)
Prostate cancer is the second most common cancer among men. We designed and synthesized new ligands targeting prostate-specific membrane antigen and suitable for bimodal conjugates with diagnostic and therapeutic agents. In vitro studies of the affin
Externí odkaz:
https://doaj.org/article/a8378698c0ce4a6eae024f4e4f123eb9