Preclinical Evaluation of [18F]FACH in Healthy Mice and Piglets: An 18F-Labeled Ligand for Imaging of Monocarboxylate Transporters with PET

Autor: Gündel, Daniel, Sadeghzadeh, Masoud, Deuther-Conrad, Winnie, Wenzel, Barbara, Cumming, Paul, Toussaint, Magali, Ludwig, Friedrich-Alexander, Moldovan, Rareş-Petru, Kranz, Mathias, Teodoro, Rodrigo, Sattler, Bernhard, Sabri, Osama, Brust, Peter

The expression of monocarboxylate transporters (MCTs) is linked to pathophysiological changes in diseases, including cancer, such that MCTs could potentially serve as diagnostic markers or therapeutic targets. We recently developed [18F]FACH as a rad

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A90124
https://ul.qucosa.de/api/qucosa%3A90124/attachment/ATT-0/

Development of Novel Analogs of the Monocarboxylate Transporter Ligand FACH and Biological Validation of One Potential Radiotracer for Positron Emission Tomography (PET) Imaging

Autor: Masoud Sadeghzadeh, Barbara Wenzel, Daniel Gündel, Winnie Deuther-Conrad, Magali Toussaint, Rareş-Petru Moldovan, Steffen Fischer, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Gerrit Schüürmann, Venkatram R. Mereddy, Lester R. Drewes, Peter Brust

Publikováno v: Molecules, Vol 25, Iss 10, p 2309 (2020)

Monocarboxylate transporters 1-4 (MCT1-4) are involved in several metabolism-related diseases, especially cancer, providing the chance to be considered as relevant targets for diagnosis and therapy. [18F]FACH was recently developed and showed very pr

Externí odkaz: https://doaj.org/article/0dea2432e8824c31a2e76d505164a53f

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Monocarboxylate transporters in cancer

Autor: Vincent F. Van Hée, Paolo E. Porporato, Valéry Payen, Erica Mina, Pierre Sonveaux

Publikováno v: Molecular Metabolism, Vol. 33, p. 48-66 (2020)
Molecular Metabolism, Vol 33, Iss, Pp 48-66 (2020)
Molecular metabolism, (2019)
Molecular Metabolism

Background Tumors are highly plastic metabolic entities composed of cancer and host cells that can adopt different metabolic phenotypes. For energy production, cancer cells may use 4 main fuels that are shuttled in 5 different metabolic pathways. Glu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6022f46eae6b751ed3db901ac18bbe
https://doi.org/10.1016/j.molmet.2019.07.006

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