Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry.

Autor: Kalaba, Predrag¹ (AUTHOR) predrag.kalaba@univie.ac.at, Pacher, Katharina¹ (AUTHOR) katharina.pacher@gmx.net, Neill, Philip John¹ (AUTHOR) phneill@gmx.at, Dragacevic, Vladimir¹ (AUTHOR) dragacevicvladimir@gmail.com, Zehl, Martin^2,3 (AUTHOR) martin.zehl@univie.ac.at, Wackerlig, Judith¹ (AUTHOR) judith.wackerlig@univie.ac.at, Kirchhofer, Michael¹ (AUTHOR) mikey.k.mb@gmail.com, Sartori, Simone B.⁴ (AUTHOR) simone.sartori@uibk.ac.at, Gstach, Hubert¹ (AUTHOR) hubert.gstach@univie.ac.at, Kouhnavardi, Shima¹ (AUTHOR) shima.kouhnavardi@gmail.com, Fabisikova, Anna² (AUTHOR) anna.fabisikova@univie.ac.at, Pillwein, Matthias¹ (AUTHOR) matthias.pillwein@icloud.com, Monje-Quiroga, Francisco⁵ (AUTHOR) francisco.monjequiroga@meduniwien.ac.at, Ebner, Karl⁴ (AUTHOR) karl.ebner@uibk.ac.at, Prado-Roller, Alexander⁶ (AUTHOR) alexander.roller@univie.ac.at, Singewald, Nicolas⁴ (AUTHOR) nicolas.singewald@uibk.ac.at, Urban, Ernst¹ (AUTHOR) ernst.urban@univie.ac.at, Langer, Thierry¹ (AUTHOR) thierry.langer@univie.ac.at, Pifl, Christian⁷ (AUTHOR) christian.pifl@meduniwien.ac.at, Lubec, Jana⁸ (AUTHOR) jana.aradska@gmail.com

Publikováno v: Biomolecules (2218-273X). Sep2023, Vol. 13 Issue 9, p1415. 40p.

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Autor: Lata, Sneh, Dhir, Ashish, Kessar, S.V., Singh, K.N., Kulkarni, S.K., Singh, Pushpinder

Publikováno v: In Results in Chemistry January 2022 4

Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry

Autor: Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec

Publikováno v: Biomolecules, Vol 13, Iss 9, p 1415 (2023)

The high structural similarity, especially in transmembrane regions, of dopamine, norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of human isoforms, make the specific targeting of individual transporters rath

Externí odkaz: https://doaj.org/article/206825143bfe4497bebe4460b140ad5d

Synthesis and evaluation of variably substituted N-methyl tetrahydroisoquinolines and benzazepines as monoamine reuptake inhibitors

Autor: Sneh Lata, Ashish Dhir, S.V. Kessar, K.N. Singh, S.K. Kulkarni, Pushpinder Singh

Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100352- (2022)

The use of N-methyl-1, 2, 3, 4-tetrahydroisoquinoline as pharmacophores has been studied over the years. It has a structural similarity with the N, N-dimethyl phenethylamine, a framework entrenched in the drug venlafaxine, acknowledged for its antide

Externí odkaz: https://doaj.org/article/37c0cb417cb640a2b1897df1db70223f

Relative Contributions of Norepinephrine and Serotonin Transporters to Antinociceptive Synergy between Monoamine Reuptake Inhibitors and Morphine in the Rat Formalin Model.

Autor: Shen, Fei¹ fshen@theravance.com, Tsuruda, Pamela R.², Smith, Jacqueline A. M.², Obedencio, Glenmar P.², Martin, William J.¹

Publikováno v: PLoS ONE. Sep2013, Vol. 8 Issue 9, p1-11. 11p.