Zobrazeno 1 - 10
of 5 176
pro vyhledávání: '"monoamine oxidase B"'
Autor:
Haydara Ammar Hasan, Jiseong Lee, Sunil Kumar, Saleh Alfarraj, Sulaiman Ali Alharbi, Manu Pant, Hoon Kim, Bijo Mathew
Publikováno v:
Applied Biological Chemistry, Vol 67, Iss 1, Pp 1-10 (2024)
Abstract Five dimethylamino-based chalcone derivatives (AC) were synthesized and evaluated for their inhibition degree against monoamine oxidase (MAO) enzymes. All AC compounds showed better inhibitory activity against MAO-B than that against MAO-A.
Externí odkaz:
https://doaj.org/article/983fa1a2e9fa4d23beeee245f329c0a7
Autor:
Moyad Shahwan, Pratibha Prasad, Dharmendra Kumar Yadav, Nojood Altwaijry, Mohd Shahnawaz Khan, Anas Shamsi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Depression and Parkinson’s disease (PD) are devastating psychiatric and neurological disorders that require the development of novel therapeutic interventions. Drug repurposing targeting predefined pharmacological targets is a widely use approach i
Externí odkaz:
https://doaj.org/article/0d5ec773e5514665a777f908e912f3b6
Autor:
Yu Fan, Jincai Wang, Jingyi Jian, Yalei Wen, Jiahao Li, Hao Tian, Jacques Crommen, Wei Bi, Tingting Zhang, Zhengjin Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1772-1786 (2024)
Human monoamine oxidase B (hMAO-B) has emerged as a pivotal therapeutic target for Parkinson's disease. Due to adverse effects and shortage of commercial drugs, there is a need for novel, highly selective, and reversible hMAO-B inhibitors with good b
Externí odkaz:
https://doaj.org/article/84afd67317434a5b9c4c7d5d54381712
Akademický článek
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Autor:
Sunil Kumar, Ratul Bhowmik, Jong Min Oh, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rasha Hamed Al‑Serwi, Hoon Kim, Bijo Mathew
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Monoamine oxidases (MAOs), specifically MAO-A and MAO-B, play important roles in the breakdown of monoamine neurotransmitters. Therefore, MAO inhibitors are crucial for treating various neurodegenerative disorders, including Parkinson's dise
Externí odkaz:
https://doaj.org/article/9e575b3ed40547a2878ec981ba070d6e
Autor:
Denis R. Khusainov, Albina N. Lukyanceva, Natalya S. Tribrat, Elena A. Biryukova, Elena N. Chuyan, Ivan I. Korenyuk, Karine N. Tumanyants, Ekaterina V. Kashutina
Publikováno v:
Siberian Journal of Life Sciences and Agriculture, Vol 15, Iss 6, Pp 29-50 (2023)
Notoriously that motor and research activities are gradually oppressed up to complete suppression during the daily testing of animals. Generally, an animal stops researching the test space and demonstrates the passive behavior. In the past studies on
Externí odkaz:
https://doaj.org/article/0b3eea1a2b2d462f811cf446bd82d857
Autor:
Riyan Alifbi Putera Irsal, Gusnia Meilin Gholam, Dzikri Anfasa Firdaus, Novian Liwanda, Fernanda Chairunisa
Publikováno v:
Borneo Journal of Pharmacy, Vol 7, Iss 2 (2024)
Parkinson's disease is a global health challenge affecting over 10 million individuals worldwide, leading to increased disability-adjusted life years (DALYs) and a rise in mortality rates. This study explores the potential anti-Parkinson's properties
Externí odkaz:
https://doaj.org/article/3ad72a8cba424571b768ba52ececa4c6
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23407- (2024)
Dysphagia, a potentially fatal symptom of Parkinson's disease, is characterized by frequent silent aspiration, a risk factor for aspiration pneumonia. The transdermal dopamine agonist rotigotine alleviates dysphagia in patients with Parkinson's disea
Externí odkaz:
https://doaj.org/article/a467fb7b16a3449a92b816000a4cee25
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Akademický článek
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