Zobrazeno 1 - 10
of 264
pro vyhledávání: '"molecular scaffolds"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
In nature, metabolic pathways are often organized into complex structures such as multienzyme complexes, enzyme molecular scaffolds, or reaction microcompartments. These structures help facilitate multi-step metabolic reactions. However, engineered m
Externí odkaz:
https://doaj.org/article/623a932a617f45bcbea4c0b37df53087
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 200-211 (2020)
The Cu-catalyzed multicomponent ketone–amine–alkyne (KA2) reaction was combined with a Pauson–Khand cycloaddition to give access of unprecedented constrained spirocyclic pyrrolocyclopentenone derivatives following a DOS couple-pair approach. Th
Externí odkaz:
https://doaj.org/article/0aa7afa4c3e1487491a29a93936e3d22
Autor:
Barbara Herlah, Andrej Hoivik, Luka Jamšek, Katja Valjavec, Norio Yamamoto, Tyuji Hoshino, Krištof Kranjc, Andrej Perdih
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 539 (2022)
The emergence of SARS-CoV-2, responsible for the global COVID-19 pandemic, requires the rapid development of novel antiviral drugs that would contribute to an effective treatment alongside vaccines. Drug repurposing and development of new molecules t
Externí odkaz:
https://doaj.org/article/8d0e56a5c12d46d488d1637e278c88c0
Publikováno v:
Emerging Topics in Life Sciences
Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population more suscept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abf41e4d63f3a1945a0972da28193ac
http://europepmc.org/articles/PMC8589427
http://europepmc.org/articles/PMC8589427
Publikováno v:
Neuronal Signaling
The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding extracellular matrix (ECM), is an important interface between the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdef93861431567d0da4eab9ac3b703b
https://doi.org/10.1042/ns20210027
https://doi.org/10.1042/ns20210027
Autor:
Lorenzo Moroni, Carlos Mota, Gabriele Addario, Maaike F J Fransen, Carlijn V. C. Bouten, Franck Halary
Publikováno v:
Essays in Biochemistry, 65(3), 587-602. Portland Press Ltd.
Essays in Biochemistry
Essays in Biochemistry
The number of patients with end-stage renal disease is continuously increasing worldwide. The only therapies for these patients are dialysis and organ transplantation, but the latter is limited due to the insufficient number of donor kidneys availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cabad2d6e139c7d4343686367c2603
https://research.tue.nl/nl/publications/13ee17de-17fa-4922-8d7c-a613d9a1254e
https://research.tue.nl/nl/publications/13ee17de-17fa-4922-8d7c-a613d9a1254e
Publikováno v:
Bioscience Reports
Basement membranes (BMs) are highly specialised extracellular matrix (ECM) structures that within the heart underlie endothelial cells (ECs) and surround cardiomyocytes and vascular smooth muscle cells. They generate a dynamic and structurally suppor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8550d9f2cec6e8b37d6263c4ac7b085a
https://eprints.gla.ac.uk/250073/1/250073.pdf
https://eprints.gla.ac.uk/250073/1/250073.pdf
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Wannisa Khamaikawin, Somphot Saoin, Sawitree Nangola, Koollawat Chupradit, Supachai Sakkhachornphop, Sudarat Hadpech, Nattawat Onlamoon, Aftab A Ansari, Siddappa N Byrareddy, Pierre Boulanger, Saw-See Hong, Bruce E Torbett, Chatchai Tayapiwatana
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Designed molecular scaffolds have been proposed as alternative therapeutic agents against HIV-1. The ankyrin repeat protein (AnkGAG1D4) and the zinc finger protein (2LTRZFP) have recently been characterized as intracellular antivirals, but these mole
Externí odkaz:
https://doaj.org/article/a4103c46f0d64e7d91d4b3e04c620245
Autor:
Isabelle S Lucet, Onisha Patel, Samuel N. Young, M.J. Roy, Minglyanna Surudoi, Laura F. Dagley, Toby A. Dite, James M. Murphy, Christopher R Horne, Peter W. Janes, Jarrod J. Sandow, Jeffrey J. Babon, Lung-Yu Liang
Publikováno v:
Biochemical Journal
EphB6 and EphA10 are two poorly characterised pseudokinase members of the Eph receptor family, which collectively serves as mediators of contact-dependent cell–cell communication to transmit extracellular cues into intracellular signals. As per the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9e5a34b01dce60b7c6552d8f3cadc3
https://pubmed.ncbi.nlm.nih.gov/34431498
https://pubmed.ncbi.nlm.nih.gov/34431498