Zobrazeno 1 - 10
of 426
pro vyhledávání: '"molecular glue"'
Autor:
Ziqi Huang, Kun Zhang, Yurui Jiang, Mengmeng Wang, Mei Li, Yuda Guo, Ruolin Gao, Ning Li, Chenyang Wang, Jia Chen, Jiefu Wang, Ning Liu, Xiang Liu, Shuangwei Liu, Mingming Wei, Cheng Yang, Guang Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4001-4013 (2024)
Cancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy. Recently, 3-phosphoglycerate dehydrogenas
Externí odkaz:
https://doaj.org/article/f12cd5184227441eb476af3f499d3c9a
Autor:
Pengyun Li, Xiaotong Hu, Zhiya Fan, Shiyang Sun, Qijie Ran, Ting Wei, Pengli Wei, Qiyu Jiang, Jian Yan, Ning Yang, Changkai Jia, Tingting Yang, Yaqiu Mao, Xu Cai, Tingting Xu, Zhiyuan Zhao, Xiaohong Qian, Weijie Qin, Xiaomei Zhuang, Feng Fan, Junhai Xiao, Zhibing Zheng, Song Li
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-30 (2024)
Abstract Background Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy. Nevertheless, the persistence of inevitable drug resistance and hematolog
Externí odkaz:
https://doaj.org/article/53485170677d439b9bf56471960e9a2e
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-24 (2024)
Abstract Targeted therapies, such as small molecule kinase inhibitors, have made significant progress in the treatment of hematologic malignancies by directly modulating protein activity. However, issues such as drug toxicity, drug resistance due to
Externí odkaz:
https://doaj.org/article/44aa040c0e97457dbd58f150108b00d7
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Targeted Protein Degradation (TPD) represented by Proteolysis-Targeting Chimeras (PROTAC) is the frontier field in the research and development of antitumor therapy, in which oral drug HP518 Receives FDA Proceed Authorization for its IND Application
Externí odkaz:
https://doaj.org/article/69b79d6e2cb74a5593b7dd1c9fce8fd4
Autor:
Ma, Haowen a, b, 1, Liu, Cong b, 1, Li, Zihao b, 1, Yu, Qiuchun b, Xiong, Huilan b, Huang, Chaomin c, Tan, Li a, ⁎⁎, Zhan, Min d, ⁎⁎⁎, Zhang, Zhang b, c, ⁎⁎⁎⁎, Cai, Qian a, b, ⁎
Publikováno v:
In European Journal of Medicinal Chemistry 5 February 2025 283
Autor:
Xiaopeng Peng, Zhihao Hu, Limei Zeng, Meizhu Zhang, Congcong Xu, Benyan Lu, Chengpeng Tao, Weiming Chen, Wen Hou, Kui Cheng, Huichang Bi, Wanyi Pan, Jianjun Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 533-578 (2024)
Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators (e.g., inhibitors). However, epigene
Externí odkaz:
https://doaj.org/article/e9f9f251319d4fdf92ac3cb5930c5c4c
Publikováno v:
SLAS Discovery, Vol 29, Iss 5, Pp 100165- (2024)
We report the development of a 384-well formatted NanoBRET assay to characterize molecular glues of 14-3-3/client interactions in living cells. The seven isoforms of 14-3-3 are dimeric hub proteins with diverse roles including transcription factor re
Externí odkaz:
https://doaj.org/article/85badde1d71a4181978e99532b926ef2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Targeted protein degradation (TPD) is a rapidly expanding field, with various PROTACs (proteolysis-targeting chimeras) in clinical trials and molecular glues such as immunomodulatory imide drugs (IMiDs) already well established in the treatment of ce
Externí odkaz:
https://doaj.org/article/e0ff70d75267414ca024682086e6d311
Publikováno v:
SLAS Discovery, Vol 29, Iss 2, Pp 100136- (2024)
Molecular glues are small molecules, typically smaller than PROTACs, and usually with improved physicochemical properties that aim to stabilise the interaction between two proteins. Most often this approach is used to improve or induce an interaction
Externí odkaz:
https://doaj.org/article/211efed96a7d4fd58ebdc2e2a1299777
Autor:
Changxin Zhong, Rongfeng Zhu, Ting Jiang, Sheng Tian, Xiaobao Zhao, Xiaoya Wan, Shilong Jiang, Zonglin Chen, Rong Gong, Linhao He, Jin‐Ming Yang, Na Ye, Yan Cheng
Publikováno v:
Advanced Science, Vol 11, Iss 5, Pp n/a-n/a (2024)
Abstract Dysregulated eEF2K expression is implicated in the pathogenesis of many human cancers, including triple‐negative breast cancer (TNBC), making it a plausible therapeutic target. However, specific eEF2K inhibitors with potent anti‐cancer a
Externí odkaz:
https://doaj.org/article/a8feaa9fb69f4b188810e9844dd4c7be