Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389

Autor: Yoichi Hayakawa, Kazuo Shin-ya, Tomohiro Yoshida, Shoko Kimata

Publikováno v: The Journal of Antibiotics. 74:76-79

A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd5b055d3841c8c4350d978b52d1a43
https://doi.org/10.1038/s41429-020-0356-8

The stress-inducible molecular chaperone GRP78 as potential therapeutic target for coronavirus infection

Autor: Amy S. Lee, Richard Van Krieken, Anthony J. Carlos, Dat P. Ha

Publikováno v: Journal of Infection
The Journal of Infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4e9dad5dfd7559482dae587592b2a0

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Comparable Autoantibody Serum Levels against Amyloid- and Inflammation-Associated Proteins in Parkinson’s Disease Patients and Controls

Autor: Maetzler, Walter, Apel, Anja, Langkamp, Markus, Deuschle, Christian, Dilger, Sarah Selina, Stirnkorb, Johannes Georg, Schulte, Claudia, Schleicher, Erwin, Gasser, Thomas, Berg, Daniela

Publikováno v: PLoS ONE
PLOS ONE 9(2), e88604 (2014). doi:10.1371/journal.pone.0088604
PLoS ONE.-San Francisco : PloS one; 2014.-S.e88604:1-e88604:6.
PLoS ONE, Vol 9, Iss 2, p e88604 (2014)

Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ec0c8d81a24b6987c30a442e0ab184d5
http://europepmc.org/articles/PMC3931625

Absolute structure of prunustatin A, a novel GRP78 molecular chaperone down-regulator

Autor: Takayuki Doi, Hidenori Watanabe, Miho Izumikawa, Kazuo Shin-ya, Yukiko Umeda, Shohei Sakuda, Ken Ishigami, Hiromichi Nagasawa, Yoichi Nakao, Motoki Takagi, Kazuo Furihata

Publikováno v: Organic letters. 9(21)

In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The planar structure of prunus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81329b213a6a085352517fb06fdcdbd4
https://pubmed.ncbi.nlm.nih.gov/17887691