ReCodLiver0.9: Overcoming Challenges in Genome-Scale Metabolic Reconstruction of a Non-model Species

Autor: Eileen Marie Hanna, Xiaokang Zhang, Marta Eide, Shirin Fallahi, Tomasz Furmanek, Fekadu Yadetie, Daniel Craig Zielinski, Anders Goksøyr, Inge Jonassen

Publikováno v: Frontiers in Molecular Biosciences, Vol 7 (2020)

The availability of genome sequences, annotations, and knowledge of the biochemistry underlying metabolic transformations has led to the generation of metabolic network reconstructions for a wide range of organisms in bacteria, archaea, and eukaryote

Externí odkaz: https://doaj.org/article/a0681cf3d3f843ef87d0c0d8e6c2846c

Using Gene Essentiality and Synthetic Lethality Information to Correct Yeast and CHO Cell Genome-Scale Models

Autor: Ratul Chowdhury, Anupam Chowdhury, Costas D. Maranas

Publikováno v: Metabolites, Vol 5, Iss 4, Pp 536-570 (2015)

Essentiality (ES) and Synthetic Lethality (SL) information identify combination of genes whose deletion inhibits cell growth. This information is important for both identifying drug targets for tumor and pathogenic bacteria suppression and for flaggi

Externí odkaz: https://doaj.org/article/760ca64a9c244b70acc092dfdcb7102d

Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process

Autor: Cyrielle Calmels, Andréa McCann, Laetitia Malphettes, Mikael Rørdam Andersen

Publikováno v: Calmels, C, McCann, A, Malphettes, L & Andersen, M R 2018, ' Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process ', Metabolic Engineering, vol. 51, pp. 9-19 . https://doi.org/10.1016/j.ymben.2018.09.009
Metabolic Engineering

CHO cells have become the favorite expression system for large scale production of complex biopharmaceuticals. However, industrial strategies for upstream process development are based on empirical results, due to a lack of fundamental understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feceaf540d562969625b89480b1054e1
https://doi.org/10.1016/j.ymben.2018.09.009

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