Cancer-Selective Targeting of the NF-kappa B Survival Pathway with GADD45 beta/MKK7 Inhibitors

Autor: Tornatore, Laura, Sandomenico, Annamaria, Raimondo, Domenico, Low, Caroline, Rocci, Alberto, Tralau-Stewart, Cathy, Capece, Daria, D'Andrea, Daniel, Bua, Marco, Boyle, Eileen, van Duin, Mark, Zoppoli, Pietro, Jaxa-Chamiec, Albert, Thotakura, Anil K., Dyson, Julian, Walker, Brian A., Leonardi, Antonio, Chambery, Angela, Driessen, Christoph, Sonneveld, Pieter, Morgan, Gareth, Palumbo, Antonio, Tramontano, Anna, Rahemtulla, Amin, Ruvo, Menotti, Franzoso, Guido

Publikováno v: Cancer Cell, 26(4), 495-508. Cell Press
Cancer cell
26 (2014): 495–508. doi:10.1016/j.ccr.2014.07.027
info:cnr-pdr/source/autori:Tornatore, Laura; Sandomenico, Annamaria; Raimondo, Domenico; Low, Caroline; Rocci, Alberto; Tralau-Stewart, Cathy; Capece, Daria; D'Andrea, Daniel; Bua, Marco; Boyle, Eileen; van Duin, Mark; Zoppoli, Pietro; Jaxa-Chamiec, Albert; Thotakura, Anil K.; Dyson, Julian; Walker, Brian A.; Leonardi, Antonio; Chambery, Angela; Driessen, Christoph; Sonneveld, Pieter; Morgan, Gareth; Palumbo, Antonio; Tramontano, Anna; Rahemtulla, Amin; Ruvo, Menotti; Franzoso, Guido/titolo:Cancer-Selective Targeting of the NF-kappa B Survival Pathway with GADD45 beta%2FMKK7 Inhibitors/doi:10.1016%2Fj.ccr.2014.07.027/rivista:Cancer cell (Print)/anno:2014/pagina_da:495/pagina_a:508/intervallo_pagine:495–508/volume:26

Constitutive NF-B-K signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-B-K-targeting strategies lack cancer cell specificity. Here, we identify the interaction between the NF-B-K-regulated antiapoptotic factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::81eef247a238dfaffeb8415075fcddb4
http://hdl.handle.net/11591/195854

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