Zobrazeno 1 - 10
of 283
pro vyhledávání: '"mixed-effect modeling"'
Autor:
Hannah A. Mattes, Shang Gao, Grant M. Graves, Keith Strevett, Jason R. Vogel, Thomas M. Neeson
Publikováno v:
Journal of Freshwater Ecology, Vol 39, Iss 1 (2024)
The reuse of wastewater for beneficial purposes (e.g. irrigation) can boost water sustainability, but may have positive or negative impacts on the environment. In some drought-prone or over-allocated river basins, wastewater is an important component
Externí odkaz:
https://doaj.org/article/a7a9a521701344ad97eab7bd73a24bbc
Autor:
Vitaly V. Ganusov
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 10 (2024)
Mathematical modeling is a powerful method to understand how biological systems work. By creating a mathematical model of a given phenomenon one can investigate which model assumptions are needed to explain the phenomenon and which assumptions can be
Externí odkaz:
https://doaj.org/article/74830ab4dc4f4ec59ed7d67890ff74b0
Autor:
Jinha Park, Se Hee Kim, Jongsung Hahn, Hoon-Chul Kang, Sang-Guk Lee, Heung Dong Kim, Min Jung Chang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Everolimus is an inhibitor of mammalian target of rapamycin complex 1. As mutations in TSC1 and TSC2, which cause partial-onset seizures associated with TSC, were found in focal cortical dysplasia type Ⅱ (FCD Ⅱ) patients, a clinical t
Externí odkaz:
https://doaj.org/article/563b1d938c09451d9aacf6986bf46ffb
Autor:
Woohyoung Kim, Ji Yeong Won, Jungyu Yi, Seung Chan Choi, Sang Min Lee, Kyungran Mun, Hyeong-Seok Lim
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 301 (2024)
L-4-[(10B)]Boronophenylalanine (BPA) is an amino acid analogue with a boron-10 moiety. It is most widely used as a boron carrier in boron neutron capture therapy. In this study, a Bayesian predictive platform of blood boron concentration based on a B
Externí odkaz:
https://doaj.org/article/6099f306acb94494be130f7b18a40cef
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The aim of the present study is to investigate the quantitative effects of sodium–glucose cotransporter-2 (SGLT-2) inhibitors on the quality of life in heart failure (HF) patients. A total of 14,674 HF patients from two dapagliflozin and three empa
Externí odkaz:
https://doaj.org/article/9d28514e91ce4e7ab94ce40829d8f2d8
Autor:
Yinyi Wei, Dongni Wu, Yiyu Chen, Chunqiang Dong, Jianying Qi, Yun Wu, Rongda Cai, Siru Zhou, Chengxin Li, Lulu Niu, Tingqing Wu, Yang Xiao, Taotao Liu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: To investigate the factors influencing the pharmacokinetics of mycophenolate mofetil (MMF) in pediatric patients after liver transplantation, and to establish a population pharmacokinetics model, which can provide a reference for clinical
Externí odkaz:
https://doaj.org/article/78ac3df791dd41cb9700a3e72156b679
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The heart rate during atrial fibrillation (AF) is highly dependent on the conduction properties of the atrioventricular (AV) node. These properties can be affected using β-blockers or calcium channel blockers, mainly chosen empirically. Characteriza
Externí odkaz:
https://doaj.org/article/5099b2d3028441a0a2d90532ae4736d8
Autor:
Julius S. Ngwa, Howard J. Cabral, Debbie M. Cheng, David R. Gagnon, Michael P. LaValley, L. Adrienne Cupples
Publikováno v:
BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-12 (2021)
Abstract Background Statistical methods for modeling longitudinal and time-to-event data has received much attention in medical research and is becoming increasingly useful. In clinical studies, such as cancer and AIDS, longitudinal biomarkers are us
Externí odkaz:
https://doaj.org/article/4ca62321ace84235ad45edaf2af1d98e
Publikováno v:
Breast Cancer: Targets and Therapy, Vol Volume 13, Pp 87-105 (2021)
Brett Fleisher,1 Jovin Lezeau,1 Carolin Werkman,1 Brehanna Jacobs,1 Sihem Ait-Oudhia2 1Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida, USA; 2Quantitative
Externí odkaz:
https://doaj.org/article/8dda878016844652aa008ca4b27c0c14
Publikováno v:
IEEE Access, Vol 9, Pp 135343-135353 (2021)
Background: Accurate and reliable prediction of changes in the severity of cerebellar ataxia (CA) will be necessary for trials of disease-modifying therapies. Cerebellar dysarthria (CD) is a common feature of CA. This study demonstrated that objectiv
Externí odkaz:
https://doaj.org/article/71c932b2dcca468788e1f62d7c4fa5d1