Zobrazeno 1 - 10
of 1 796
pro vyhledávání: '"mitochondrial translation"'
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-26 (2024)
Abstract Due to spatial and genomic independence, mitochondria possess a translational mechanism distinct from that of cytoplasmic translation. Several regulators participate in the modulation of mitochondrial translation. Mitochondrial translation i
Externí odkaz:
https://doaj.org/article/3ab741565df740ecaeaa0b3daf823355
Publikováno v:
FEBS Open Bio, Vol 14, Iss 10, Pp 1640-1655 (2024)
Mitoribosome biogenesis is a complex process involving RNA elements encoded in the mitochondrial genome and mitoribosomal proteins typically encoded in the nuclear genome. This process is orchestrated by extra‐ribosomal proteins, nucleus‐encoded
Externí odkaz:
https://doaj.org/article/bfdcc70812bc44fabd9d7e766610350e
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-18 (2023)
Abstract Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co-encode the subunits of the oxidative phosphorylation (OXPHOS) complex, is criti
Externí odkaz:
https://doaj.org/article/b952421ad4444045b12309e428dbde7b
Autor:
Catarina Maria Almeida, Esmeralda Rodrigues, Teresa Almeida Campos, Laura Vilarinho, Elisa Leão Teles
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract Background Mitochondrial diseases are a group of rare inborn metabolic disorders with multi-systemic manifestations. MTO1 gene mutations are associated with MTO1 (Mitochondrial tRNA Translation Optimization 1) protein deficiency, a mitochond
Externí odkaz:
https://doaj.org/article/523b6cb7a83a4ea8afe344e06b693799
Autor:
Miaomiao Guo, Xinhua Qiao, Yuanyuan Wang, Zi-Han Li, Chang Shi, Yun Chen, Lu Kang, Chang Chen, Xiao-Long Zhou
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102722- (2023)
Aminoacyl-tRNA synthetases (aaRSs) are indispensable players in translation. Usually, two or three genes encode cytoplasmic and mitochondrial threonyl-tRNA synthetases (ThrRSs) in eukaryotes. Here, we reported that Caenorhabditis elegans harbors only
Externí odkaz:
https://doaj.org/article/7b77cd7367aa4096a4cf037e944c627c
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background The establishment and maintenance of functional neural connections relies on appropriate distribution and localization of mitochondria in neurites, as these organelles provide essential energy and metabolites. In particular, mitoc
Externí odkaz:
https://doaj.org/article/9632e7d0080a406aa81e603bc08408cc
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionOvarian cancer is one of the leading causes of death for women with cancer worldwide. Energy requirements for tumor growth in epithelial high-grade serous ovarian cancer (HGSOC) are fulfilled by a combination of aerobic glycolysis and oxi
Externí odkaz:
https://doaj.org/article/f218794147364829983a3154f0345539
Autor:
Gautam Pareek
Publikováno v:
PeerJ, Vol 10, p e14350 (2022)
Mitochondria play essential cellular roles in Adenosine triphosphate (ATP) synthesis, calcium homeostasis, and metabolism, but these vital processes have potentially deadly side effects. The production of the reactive oxygen species (ROS) and the agg
Externí odkaz:
https://doaj.org/article/132448638ae342ad83d52c22d9a5ad9b
Publikováno v:
Life, Vol 13, Iss 9, p 1863 (2023)
In mammalian mitochondria, the processing of primary RNA transcripts involves a coordinated series of cleavage and modification events, leading to the formation of processing intermediates and mature mt-RNAs. RNA19 is an unusually stable unprocessed
Externí odkaz:
https://doaj.org/article/c477075f692045198e39b5d490f0556c
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Remodeling of mitochondrial energy metabolism is essential for the survival of tumor cells in limited nutrient availability and hypoxic conditions. Defects in oxidative phosphorylation (OXPHOS) and mitochondrial biogenesis also cause a switch in ener
Externí odkaz:
https://doaj.org/article/3d474ea12a3d46eab1e6377a484ad2f4