Zobrazeno 1 - 10
of 796
pro vyhledávání: '"mitochondrial transcription factor A"'
Autor:
Min Guo, Junhao Zhang, Jiang Han, Yingyue Hu, Hao Ni, Juan Yuan, Yang Sun, Meijuan Liu, Lifen Gao, Wangjun Liao, Chunhong Ma, Yaou Liu, Shuijie Li, Nailin Li
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background Glioblastoma is an aggressive brain tumor linked to significant angiogenesis and poor prognosis. Anti-angiogenic therapies with vascular endothelial growth factor receptor 2 (VEGFR2) inhibition have been investigated as an alterna
Externí odkaz:
https://doaj.org/article/712e2c19a1cc46c991715955dd112874
Autor:
Longqing Zhang, Xi Tan, Fanhe Song, Danyang Li, Jiayi Wu, Shaojie Gao, Jia Sun, Daiqiang Liu, Yaqun Zhou, Wei Mei
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 3, Pp 687-696 (2024)
[INLINE:1] Activated G-protein-coupled receptor 39 (GPR39) has been shown to attenuate inflammation by interacting with sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α). However, whether GPR39 attenuates n
Externí odkaz:
https://doaj.org/article/ca49ab450884405cab71986702925e8d
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Previous studies have shown that depression is often accompanied by an increase in mtDNA copy number and a decrease in ATP levels; however, the exact regulatory mechanisms remain unclear. Methods In the present study, Western blot
Externí odkaz:
https://doaj.org/article/09f10cdc75c6461597383c1c35ffbd0b
Publikováno v:
Redox Report, Vol 27, Iss 1, Pp 128-138 (2022)
Objectives Ulcerative colitis (UC), an inflammatory bowel disease, affects mucosal lining of colon leading to inflammation and ulcers. Sulforaphane is a natural compound obtained from cruciferous vegetables. We aimed to investigate potential therapeu
Externí odkaz:
https://doaj.org/article/3d21c2d9de3f4cad8a098ce44cb756b4
Akademický článek
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Autor:
Yutaro Sasaki, Toshio Norikura, Isao Matsui-Yuasa, Ritsuko Fujii, Leenawaty Limantara, Akiko Kojima-Yuasa
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17588- (2023)
Kaempferia galanga L. shows anti-cancer effects; however, the underling mechanism remains unclear. In this study, we explored the underlying mechanism of the anti-cancer effects of Kaempferia galanga L. Kaempferia galanga L. rhizome extracts (KGEs) s
Externí odkaz:
https://doaj.org/article/4c50867e15044752a62a8cca01ff20be
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 3, Pp 1215-1223 (2022)
The presence of ectopic DNA in the cytoplasm induces inflammation and cell death. It has been widely reported that leakage of nuclear DNA into the cytoplasm can mainly be sensed by cyclic GMP-AMP synthase (cGAS). We recently reported that mitochondri
Externí odkaz:
https://doaj.org/article/17ec73b607c448c684d8167d691d1ab2
Akademický článek
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Akademický článek
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Autor:
Nidhi Sharma, Marlo K. Thompson, Jennifer F. Arrington, Dava M. Terry, Srinivas Chakravarthy, Peter E. Prevelige, Aishwarya Prakash
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The maintenance of human mitochondrial DNA (mtDNA) is critical for proper cellular function as damage to mtDNA, if left unrepaired, can lead to a diverse array of pathologies. Of the pathways identified to participate in DNA repair within the mitocho
Externí odkaz:
https://doaj.org/article/1c42ca856e2647e582d990dc323a4999