Zobrazeno 1 - 10
of 4 415
pro vyhledávání: '"mitochondrial ros"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Sorafenib resistance is becoming increasingly common and disadvantageous for hepatocellular carcinoma (HCC) treatment. Ferroptosis is an iron dependent programmed cell death underlying the mechanism of sorafenib. Iron is crucial f
Externí odkaz:
https://doaj.org/article/a0d599d21c2240f1b9d402fdcd92d7fe
Autor:
Herbert Sizek, Dávid Deritei, Katherine Fleig, Marlayna Harris, Peter L. Regan, Kimberly Glass, Erzsébet Ravasz Regan
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102084- (2024)
The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, i
Externí odkaz:
https://doaj.org/article/d3964a122568414884e9a7d26148d4d4
Publikováno v:
Particle and Fibre Toxicology, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Background The global use of plastic materials has undergone rapid expansion, resulting in the substantial generation of degraded and synthetic microplastics and nanoplastics (MNPs), which have the potential to impose significant environment
Externí odkaz:
https://doaj.org/article/6e6d6b6d3cd640fabb0b463229ae9c86
Publikováno v:
Clinical and Translational Discovery, Vol 4, Iss 4, Pp n/a-n/a (2024)
Abstract Chronic airway obstructive pulmonary disease (COPD) is a preventable and curable disease characterised by persistent airflow limitation. It is characterised by chronic bronchitis and/or emphysema, and its aetiology is related to various fact
Externí odkaz:
https://doaj.org/article/5844bb5fd3b545049ef2742300be540a
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30814- (2024)
This study aimed to investigate correlation between mitochondrial reactive oxygen species and Porphyromonas gingivalis in the process of cementoblast pyroptosis. Lactate dehydrogenase activity assay, enzyme-linked immunosorbent assay, western blottin
Externí odkaz:
https://doaj.org/article/537aeaf7257c4d22ac16e744e25d2934
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dyslipidemia is the most prevalent independent risk factor for patients with chronic kidney disease (CKD). Lipid-induced NLRP3 inflammasome activation in kidney-resident cells exacerbates renal injury by causing sterile inflammation. Nuclear factor e
Externí odkaz:
https://doaj.org/article/fb1aca208c624d1d9d1bdfbddf16780e
Autor:
Panpan Tai, Xinyu Chen, Guihua Jia, Guanjun Chen, Lian Gong, Yaxin Cheng, Zhuan Li, Heng Wang, Aiyan Chen, Ganghua Zhang, Yuxing Zhu, Mengqing Xiao, Zhanwang Wang, Yunqing Liu, Dongyong Shan, Dong He, Moying Li, Tianzuo Zhan, Abbas Khan, Xiaohui Li, Xiangxiang Zeng, Chaopeng Li, Dongsheng Ouyang, Kelong Ai, Xuan Chen, Dongbo Liu, Zhonghua Liu, Dongqing Wei, Ke Cao
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a major impediment to its clinical application. It is indispensable to explore alternative treatment molecules or drugs for mitigating DIC. WGX50, an organic extract derived from Z
Externí odkaz:
https://doaj.org/article/c43918d7db784155be01f58f4016ff79
Publikováno v:
BMC Cardiovascular Disorders, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Myocardial infarction (MI) is a leading cause of mortality. To better understand its molecular and cellular mechanisms, we used bioinformatic tools and molecular experiments to explore the pathogenesis and prognostic markers. Differential ge
Externí odkaz:
https://doaj.org/article/cb76ad126a3542e5a61cf03bd5fc78ca
Publikováno v:
Cells, Vol 13, Iss 17, p 1433 (2024)
Mitochondrial malfunction, excessive production of reactive oxygen species (ROS), deficient autophagy/mitophagy, and chronic inflammation are hallmarks of age-related macular degeneration (AMD). Metformin has been shown to activate mitophagy, allevia
Externí odkaz:
https://doaj.org/article/acf3aaabe01447d4a84e333ff27fc783
Autor:
Zhen Zhang, Shujun Xie, Jin Qian, Fengqiang Gao, Wenjian Jin, Lingqiao Wang, Lili Yan, Hao Chen, Wangxiang Yao, Maoqiang Li, Xuepeng Wang, Liulong Zhu
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Background Osteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any stage, is an inflammatory arthritis. However, there are no effective targets to cure the progr
Externí odkaz:
https://doaj.org/article/dadb23f7fdf046019da150fe9cffb661