Zobrazeno 1 - 10
of 1 080
pro vyhledávání: '"mitochondrial outer membrane"'
Autor:
Shuang Wu, Ying Zhang, Lele Xu, Haibo Zhang, Yuhe Li, Leiyun Yang, Zhengguang Zhang, Haifeng Zhang
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 37, Iss 4, Pp 407-415 (2024)
Mitochondria are highly dynamic organelles that constantly change their morphology to adapt to the cellular environment through fission and fusion, which is critical for a cell to maintain normal cellular functions. Despite the significance of this p
Externí odkaz:
https://doaj.org/article/fb3199d99dc74b8b9d9f7eef2870ec92
Autor:
Qingshan Chen, Fenglin Gao, Junwan Wu, Kaiming Zhang, Tian Du, Yuhong Chen, Ruizhao Cai, Dechang Zhao, Rong Deng, Jun Tang
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 6, Pp n/a-n/a (2024)
Abstract Background Mitochondrial outer membrane permeabilisation (MOMP) plays a pivotal role in cellular death and immune activation. A deeper understanding of the impact of tumour MOMP on immunity will aid in guiding more effective immunotherapeuti
Externí odkaz:
https://doaj.org/article/43ecb89d02374b6f822f97327af205c5
Autor:
Bruno Cesar Costa Soares, Hnin Ei Ei Khine, Boonchoo Sritularak, Pithi Chanvorachote, Rosa Alduina, Rungroch Sungthong, Chatchai Chaotham
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: The upgrade of natural products for cancer treatment is essential since current anticancer drugs still pose severe side effects. Cymensifin A (Cym A) isolated from an orchid Cymbidium ensifolium has shown its potential to induce the death
Externí odkaz:
https://doaj.org/article/5541f24e39bd48deaa09a3a4d79e7318
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis. BAX, a proapoptotic BCL-2 effector, directly forms proteolipid pores in the outer mitochondrial membrane to activate the mitoch
Externí odkaz:
https://doaj.org/article/ad1c5e974e5b4f44951c3ad2fc7fdb0e
Autor:
Anna Lechado-Terradas, Sandra Schepers, Katharina I. Zittlau, Karan Sharma, Orkun Ok, Julia C. Fitzgerald, Stefan Geimer, Benedikt Westermann, Boris Macek, Philipp J. Kahle
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 576-602 (2022)
PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group of ubiquiti
Externí odkaz:
https://doaj.org/article/28921611ba294240a516a15b1a04f119
Autor:
Prasad Sulkshane, Tanuja Teni
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 3, Pp 278-296 (2022)
The antiapoptotic B cell lymphoma-2 (Bcl-2) family members are apical regulators of the intrinsic pathway of apoptosis that orchestrate mitochondrial outer membrane permeabilization (MOMP) through interactions with their proapoptotic counterparts. Ov
Externí odkaz:
https://doaj.org/article/93986c4e1e2c4b9ebc28fc2e922f3483
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021)
Abstract Objective Elamipretide (SS31) is a mitochondria-targeted peptide that has reported functions of stabilizing mitochondrial cristae structure and improving mitochondrial bioenergetics. Several studies have documented cell protective features o
Externí odkaz:
https://doaj.org/article/a0a3bdfe79184dedbcc355b0d9ece19c
Sphingolipid distribution at mitochondria-associated membranes (MAMs) upon induction of apoptosis[S]
Autor:
Vincent Mignard, Nolwenn Dubois, Didier Lanoé, Marie-Pierre Joalland, Lisa Oliver, Claire Pecqueur, Dominique Heymann, François Paris, François M. Vallette, Lisenn Lalier
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 1025-1037 (2020)
The levels and composition of sphingolipids and related metabolites are altered in aging and in common disorders such as diabetes and cancers, as well as in neurodegenerative, cardiovascular, and respiratory diseases. Changes in sphingolipids have be
Externí odkaz:
https://doaj.org/article/247efe1794124137a9bf17c73b7ff7da
Autor:
Viktor V. Lemeshko
Publikováno v:
Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales, Vol 46, Iss 178 (2022)
The main feature of fast-growing malignant tumors is the Warburg-type metabolism, which is directly related to an extremely high quantity of hexokinase (HK) bound to the voltage-dependent anion channels (VDACs) in the mitochondrial outer membrane. Pr
Externí odkaz:
https://doaj.org/article/5c07c900f0a747ed9278c3ec297a4bc0
Publikováno v:
Membranes, Vol 12, Iss 8, p 752 (2022)
Proteins can be targeted to organellar membranes by using a tail anchor (TA), a stretch of hydrophobic amino acids found at the polypeptide carboxyl-terminus. The Fis1 protein (Fis1p), which promotes mitochondrial and peroxisomal division in the yeas
Externí odkaz:
https://doaj.org/article/288e72a651804a64a8bcf9cec2f5e7e9