Zobrazeno 1 - 10
of 1 128
pro vyhledávání: '"mitochondrial homeostasis"'
Autor:
Wei He, Xin Tian, Quan Zhou, Jiaheng Lv, Yangfeng Li, Chenyang Jin, Hao Liu, Huiling Yang, Yong Xu, Fan He, Tao Liu
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-23 (2024)
Abstract Intervertebral disc degeneration (IVDD) is a prevalent musculoskeletal disorder that involves the excessive accumulation of reactive oxygen species (ROS), resulting in mitochondrial dysfunction and matrix metabolism imbalance in nucleus pulp
Externí odkaz:
https://doaj.org/article/7f155145909f45e7bdbdd81284ec3b3e
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-38 (2024)
Abstract As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effectively reverse the root changes
Externí odkaz:
https://doaj.org/article/a0844420c9744b089727234a34b5fcdb
Autor:
Yu‐Ning Fann, Wan‐Huai Teo, Hsin‐Chen Lee, Chen‐Chung Liao, Yeou‐Guang Tsay, Tung‐Fu Huang, Jeng‐Fan Lo
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 2013-2029 (2024)
Abstract Background Sarcopenic obesity is characterized by excess fat mass and diminished muscular mass/function. DNAJA3, a mitochondrial co‐chaperone protein, plays a crucial role in skeletal muscle development. GMI, an immunomodulatory protein, p
Externí odkaz:
https://doaj.org/article/f00eb42e669f4e73829ef17a155f36e0
Publikováno v:
Shipin Kexue, Vol 45, Iss 18, Pp 242-249 (2024)
Signal transducer and activator of transcription 3 (STAT3) exists in the cytoplasm, nucleus, mitochondria, and mitochondria associated endoplasmic reticulum membranes, which is a signal transduction protein involved in various physiological processes
Externí odkaz:
https://doaj.org/article/66f49ffa9911468dbba5f57e28c9e071
Autor:
Yan Qu, Bowen Meng, Simin Cai, Benyi Yang, Yifan He, Chaoran Fu, Xiangxia Li, Peiyi Li, Zeyuan Cao, Xueli Mao, Wei Teng, Songtao Shi
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Over 50 billion cells undergo apoptosis each day in an adult human to maintain tissue homeostasis by eliminating damaged or unwanted cells. Apoptotic deficiency can lead to age-related diseases with reduced apoptotic metabolites. However, wh
Externí odkaz:
https://doaj.org/article/7710790764204271b695fec2bd81a8b2
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 19 (2024)
Engaging in regular exercise and physical activity contributes to delaying the onset of cardiovascular diseases (CVDs). However, the physiological mechanisms underlying the benefits of regular exercise or physical activity in CVDs remain unclear. The
Externí odkaz:
https://doaj.org/article/68c98b29b0994c79a935c8db60660852
Autor:
Yena Cho, Yong Kee Kim
Publikováno v:
Redox Biology, Vol 76, Iss , Pp 103344- (2024)
CARM1 is predominantly localized in the nucleus and plays a pivotal role in maintaining mitochondrial homeostasis by regulating gene expression. It suppresses mitochondrial biogenesis by downregulating PGC-1α and TFAM expression, while promoting mit
Externí odkaz:
https://doaj.org/article/039c9f0a155848ca93a1d52bc98d9988
Publikováno v:
Heliyon, Vol 10, Iss 17, Pp e36470- (2024)
Alzheimer's disease (AD) is a neurological disease with memory loss and cognitive decline, which affects a large proportion of the aging population. Regrettably, there are no drug to reverse or cure AD and drug development for the primary theory of a
Externí odkaz:
https://doaj.org/article/b6815f24402e488ebb6791b73630941a
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, and its prevalence is rapidly increasing. Antioxidants, lipid-lowering medications, and lifestyle interventions are the most commonly used treatment options
Externí odkaz:
https://doaj.org/article/934dd7ffbb314799b288ace4010d9496
Autor:
Kun Jiao, Guiqin Xu, Yun Liu, Zhaojuan Yang, Lvzhu Xiang, Zehong Chen, Chen Xu, You Zuo, Zhibai Wu, Ningqian Zheng, Wangjie Xu, Li Zhang, Yongzhong Liu
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background The maintenance of mitochondrial homeostasis is critical for tumor initiation and malignant progression because it increases tumor cell survival and growth. The molecular events controlling mitochondrial integrity that facilitate
Externí odkaz:
https://doaj.org/article/e5f46d669403479184c382a6381ee28d