Zobrazeno 1 - 10
of 112
pro vyhledávání: '"mitochondria-associated ER membrane"'
Autor:
Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 2, Pp 439-461 (2023)
Background & Aims: Despite recent evidence supporting the metabolic plasticity of CD4+ T cells, it is uncertain whether the metabolic checkpoint pyruvate dehydrogenase kinase (PDK) in T cells plays a role in the pathogenesis of colitis. Methods: To i
Externí odkaz:
https://doaj.org/article/56b0f5c5afd64696a6533f36bb60da13
Autor:
Jae Ryong Lim, Chang Woo Chae, Ji Yong Park, Young Hyun Jung, Jee Hyeon Yoon, Min Jeong Kim, Hyun Jik Lee, Gee Euhn Choi, Ho Jae Han
Publikováno v:
Neurobiology of Disease, Vol 177, Iss , Pp 106009- (2023)
Heavy alcohol consumption causes neuronal cell death and cognitive impairment. Neuronal cell death induced by ethanol may result from increased production of the sphingolipid metabolite ceramide. However, the molecular mechanisms of neuronal cell dea
Externí odkaz:
https://doaj.org/article/941482575f4f4fcab6d790891c5eef29
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease with multiple etiologies, involving both genetic and environmental factors. With changes associated with modern life, increasing attention has been paid to chronic psychological stressors
Externí odkaz:
https://doaj.org/article/92c48483749c4a2b8a20d8c2a34d929d
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Background Apolipoprotein E4 (apoE4) is a major genetic risk factor of Alzheimer’s disease. Its C-terminal-truncated apoE4 (Δ272–299) has neurotoxicity by affecting mitochondrial respiratory function. However, the molecular mechanism(s)
Externí odkaz:
https://doaj.org/article/5abbfd524d1a48f994366c345c2ccff1
Akademický článek
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Autor:
Joshua J. Wang, Karen Sophia Park, Narayan Dhimal, Shichen Shen, Xixiang Tang, Jun Qu, Sarah X. Zhang
Publikováno v:
Cells, Vol 11, Iss 18, p 2819 (2022)
The mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) is the physical contact site between the ER and the mitochondria and plays a vital role in the regulation of calcium signaling, bioenergetics, and inflammation. Disturbances in the
Externí odkaz:
https://doaj.org/article/3638b81fd7a742fe9bc7be7add47c229
Autor:
Sophie Moulin, Amandine Thomas, Stefan Wagner, Michael Arzt, Hervé Dubouchaud, Frédéric Lamarche, Sophie Bouyon, Guillaume Vial, Diane Godin-Ribuot, Jean-Louis Pépin, Claire Arnaud, Elise Belaidi
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1462 (2022)
Rationale: Intermittent hypoxia (IH) is one of the main features of sleep-disordered breathing (SDB). Recent findings indicate that hypoxia inducible factor-1 (HIF-1) promotes cardiomyocytes apoptosis during chronic IH, but the mechanisms involved re
Externí odkaz:
https://doaj.org/article/910d51c4a6634f3790d2be269caebddb
Autor:
Claire Angebault, Mathieu Panel, Mathilde Lacôte, Jennifer Rieusset, Alain Lacampagne, Jérémy Fauconnier
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Besides skeletal muscle dysfunction, Duchenne muscular dystrophy (DMD) exhibits a progressive cardiomyopathy characterized by an impaired calcium (Ca2+) homeostasis and a mitochondrial dysfunction. Here we aimed to determine whether sarco-endoplasmic
Externí odkaz:
https://doaj.org/article/0a411119cf0b4166b9a42fa3aa80b272
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The endoplasmic reticulum (ER) and mitochondria are physically connected to form dedicated structural domains known as mitochondria-associated ER membranes (MAMs), which participate in fundamental biological processes, including lipid and calcium (Ca
Externí odkaz:
https://doaj.org/article/edb7519653284f6caf6a549bfec6d3bd
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 797-808 (2017)
Objective: Brown adipocytes (BAs) are endowed with a high metabolic capacity for energy expenditure due to their high mitochondria content. While mitochondrial pH is dynamically regulated in response to stimulation and, in return, affects various met
Externí odkaz:
https://doaj.org/article/c212af8769b643ecb54f7dca3aeffaff