Zobrazeno 1 - 10
of 137
pro vyhledávání: '"mitocans"'
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Mitochondria are promising drug target for cancer treatment. We previously demonstrated that a bi-gold compound BGC2a was more potent than the mono-gold drug auranofin in suppressing cancer cells due to increased gold atom number that led to higher d
Externí odkaz:
https://doaj.org/article/c19827921137433ea5c15bb0b312c67d
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The tumor microenvironment affects the structure and metabolic function of mitochondria in tumor cells. This process involves changes in metabolic activity, an increase in the amount of reactive oxygen species (ROS) in tumor cells compared to normal
Externí odkaz:
https://doaj.org/article/f477c9309fb6423ab0e68641307a9a32
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100708- (2023)
Maslinic acid was converted via a di-acetylated piperazinyl amide into rhodamine conjugates differing in their alkyl moieties. These conjugates were submitted to cytotoxicity assays employing a panel of human tumor cell lines. These conjugates held h
Externí odkaz:
https://doaj.org/article/1228924dbd1742a999a788600c673df2
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100073- (2022)
Ursolic acid was used as a convenient starting material for a three-step partial synthesis of corosolic acid. Corosolic acid was acetylated, and an amide linker was attached followed by a rhodamine B unit at the distal end of the linker. Especially c
Externí odkaz:
https://doaj.org/article/6d96264c0c43454d8fd484652daf758a
Akademický článek
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Autor:
Haseeb A. Khan, Amani A. Alghamdi, N. Rajendra Prasad, Salman H. Alrokayan, Basma S. Almansour, Ashraf A. K. Hatamilah
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 28, Iss 8, p 180 (2023)
Background: Recent studies suggest that numerous naturally occurring agents have the potential to kill cancer cells via mitochondrial dysfunction. Solanum nigrum is a herb widely used in alternative medical systems. This study aimed to investigate th
Externí odkaz:
https://doaj.org/article/df4d842f4c19447f9a278cc33122dbb4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10695 (2023)
1,5-Diazacyclooctane was prepared by a simple synthetic sequence and coupled to pentacyclic triterpenoic acids oleanolic acid, ursolic acid, betulinic acid, platanic acid, and asiatic acid; these amides were activated with oxalyl chloride and reacted
Externí odkaz:
https://doaj.org/article/bab457a40d0349a8a689e1855d945556
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-25 (2021)
Abstract Acute myeloid leukemias (AML) are a group of aggressive hematologic malignancies resulting from acquired genetic mutations in hematopoietic stem cells that affect patients of all ages. Despite decades of research, standard chemotherapy still
Externí odkaz:
https://doaj.org/article/f646a733b9bd4dca95a97fff195fe01e
Autor:
Mikhail V. Dubinin, Darya A. Nedopekina, Anna I. Ilzorkina, Alena A. Semenova, Vyacheslav A. Sharapov, Eldar V. Davletshin, Natalia V. Mikina, Yuri P. Belsky, Anna Yu. Spivak, Vladimir S. Akatov, Natalia V. Belosludtseva, Jiankang Liu, Konstantin N. Belosludtsev
Publikováno v:
Membranes, Vol 13, Iss 6, p 563 (2023)
The present work shows the cytotoxic effects of novel conjugates of ursolic, oleanolic, maslinic, and corosolic acids with the penetrating cation F16 on cancer cells (lung adenocarcinoma A549 and H1299, breast cancer cell lines MCF-7 and BT474) and n
Externí odkaz:
https://doaj.org/article/e339fd2e58c7473da384490b7ffb9826
Autor:
Mariana Castelôa, Beatriz Moreira-Pinto, Sofia Benfeito, Fernanda Borges, Bruno M. Fonseca, Irene Rebelo
Publikováno v:
Biomedicines, Vol 10, Iss 4, p 800 (2022)
Small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT) and endometrial cancer from type 1 and type 2 are gynecological tumors that affect women worldwide. The treatment encompasses the use of cytotoxic drugs that are nonspecific and ineffic
Externí odkaz:
https://doaj.org/article/a57b69372d684be48858bd2a61b3f1ca