Zobrazeno 1 - 10
of 342
pro vyhledávání: '"mismatch repair system"'
Publikováno v:
Опухоли женской репродуктивной системы, Vol 19, Iss 4, Pp 132-139 (2024)
Despite the existing standard treatments for endometrial cancer, the prognosis for these patients remained poor until recently. None of currently available cytostatics ensured long-term disease control and long-term survival of patients receiving sta
Externí odkaz:
https://doaj.org/article/60d0ae2c4915459c9ed72ec7254d4b57
Publikováno v:
Revista de Gastroenterología de México, Vol 87, Iss 4, Pp 432-438 (2022)
Resumen: Introducción y objetivos: Una tarea frecuente en el estudio de los carcinomas colorrectales (CCR) es identificar tumores que presenten sistemas defectuosos de reparación de errores de emparejamiento en el DNA (dMMR, por sus siglas en ingl
Externí odkaz:
https://doaj.org/article/42d238fe647e4e40825a98d871f52df2
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Lung squamous cell carcinoma (LUSC) shares less typical onco-drivers and target resistance, but a high overall mutation rate and marked genomic complexity. Mismatch repair (MMR) deficiency leads to microsatellite instability (MSI) and gen
Externí odkaz:
https://doaj.org/article/a7505488320c4d0f844803e9c40641cd
Publikováno v:
Journal of Molecular Pathology, Vol 2, Iss 2, Pp 93-100 (2021)
The mismatch repair (MMR) system has a key role in supporting the DNA polymerase proofreading function and in maintaining genome stability. Alterations in the MMR genes are driving events of tumorigenesis, tumor progression, and resistance to therapy
Externí odkaz:
https://doaj.org/article/3ede9e8ec6874ebea65f75d04880d32c
Autor:
Longyun Chen, Fan Yang, Ting Feng, Shafei Wu, Kaimi Li, Junyi Pang, Xiaohua Shi, Zhiyong Liang
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
BackgroundCervical small cell neuroendocrine carcinoma (SCNC) is a rare and aggressive disease that lacks a standard treatment strategy or effective methods of targeted therapy. PD-L1 inhibitors for DNA mismatch repair system-deficient (dMMR) tumors
Externí odkaz:
https://doaj.org/article/6488a8db563749d4ba311fc523634e7a
Publikováno v:
Cancer Management and Research, Vol Volume 10, Pp 105-113 (2018)
Yang-chun Feng,1,2 Wen-li Ji,3 Na Yue,3 Yan-chun Huang,2 Xiu-min Ma1 1Clinical Laboratory Center, The First Affiliated Hospital of Xinjiang Medical University, 2Clinical Laboratory Center, 3Clinical Pathology Center, Tumor Hospital Affiliated to Xinj
Externí odkaz:
https://doaj.org/article/37b42a6e1e3a48f49ec09b8e771bacb0
Publikováno v:
Journal of Ovarian Research, Vol 10, Iss 1, Pp 1-5 (2017)
Abstract Background Granulosa cell tumors are rare ovarian malignancies. Their characteristics include unpredictable indolent growth with malignant potential and late recurrence. Approximately 95% are of adult type. Recent molecular studies have char
Externí odkaz:
https://doaj.org/article/1642af849e4e4147b0827fc046d3183a
Publikováno v:
Antibiotics, Vol 9, Iss 9, p 600 (2020)
This study investigated genomic differences in Australian and Indian Pseudomonas aeruginosa isolates from keratitis (infection of the cornea). Overall, the Indian isolates were resistant to more antibiotics, with some of those isolates being multi-dr
Externí odkaz:
https://doaj.org/article/e5fd88cb43d54239b3ed65b70808c046
Autor:
Marco Maria Germani, Roberto Moretto
Publikováno v:
Cancers, Vol 14, Iss 52, p 52 (2022)
Cancers
Cancers
Simple Summary Immune-checkpoint inhibitors (ICI) show modest activity and efficacy in microsatellite stable (MSS) metastatic colorectal cancer (mCRC) patients harbouring a proficient mismatch repair system (pMMR). Recently, two phase 2 trials -Atezo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2eb18c2915cf6ac3d61874c225bbbd
https://www.mdpi.com/2072-6694/14/1/52
https://www.mdpi.com/2072-6694/14/1/52
Autor:
Federica Zito Marino, Martina Amato, Andrea Ronchi, Iacopo Panarese, Franca Ferraraccio, Ferdinando De Vita, Giuseppe Tirino, Erika Martinelli, Teresa Troiani, Gaetano Facchini, Felice Pirozzi, Michele Perrotta, Pasquale Incoronato, Raffaele Addeo, Francesco Selvaggi, Francesco Saverio Lucido, Michele Caraglia, Giovanni Savarese, Roberto Sirica, Marika Casillo, Eva Lieto, Annamaria Auricchio, Francesca Cardella, Ludovico Docimo, Gennaro Galizia, Renato Franco
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2204
Background: Microsatellite instability (MSI) is a predictive biomarker for immune checkpoint inhibitors. The main goal was to investigate the discordance between IHC and PCR/NGS for MSI testing in gastrointestinal cancers. Methods: Two series were an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467905eb266933f8005acce9e7dc7a97