Zobrazeno 1 - 10
of 569
pro vyhledávání: '"mismatch repair gene"'
Autor:
Cătălin Vasile Munteanu, Cătălin Marian, Adela Chiriță-Emandi, Maria Puiu, Adrian Pavel Trifa
Publikováno v:
BMC Genomic Data, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Lynch syndrome (LS) is one of the most common hereditary cancer syndrome in human populations, associated with germline variants in MLH1, MSH2/EPCAM, MSH6 and PMS2 genes. The advent of next generation sequencing has proven a significant impa
Externí odkaz:
https://doaj.org/article/a6119d78d567491e88e8c7def5420876
Autor:
Xiaojing Liu, Haiqing Zhu, Bao Guo, Jiahua Chen, Junhui Zhang, Tao Wang, Jing Zhang, Wenjun Shan, Junchi Zou, Yunxia Cao, Bing Wei, Lei Zhan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The innate immune molecule NLR family CARD domain-containing 5 (NLRC5) plays a significant role in endometrial carcinoma (EC) immunosurveillance. However, NLRC5 also plays a protumor role in EC cells. Mismatch repair gene deficiency (dMMR) c
Externí odkaz:
https://doaj.org/article/41ec07cd9fba40bda73fd4db7857a8d0
Autor:
Zijian Deng, Yajun Luo, Xiaoli Chen, Tao Pan, Yuanyi Rui, Hai Hu, Jin Yan, Ke Zhang, Cheng Luo, Bo Song
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn recent years, there has been significant research interest in immunotherapy for colorectal cancer (CRC). Specifically, immunotherapy has emerged as the primary treatment for patients with mismatch repair gene defects (dMMR) or microsatel
Externí odkaz:
https://doaj.org/article/fe3d5d3a186a413497a4c9e1e9ef5771
Autor:
Tiansong Zhang, Xiaoqiang Huang, Wenjie Liu, Xiulan Ling, Zhenping Su, Mengwei Huang, Shuanlong Che
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-8 (2024)
Abstract Background Multiple primary malignancies are rare in cancer patients, and risk factors may include genetics, viral infection, smoking, radiation, and other environmental factors. Lynch syndrome (LS) is the most prevalent form of hereditary p
Externí odkaz:
https://doaj.org/article/534f5e82f93f4ec5b034a2ea200c8f07
Publikováno v:
Middle East Journal of Cancer, Vol 14, Iss 2, Pp 300-308 (2023)
Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes. Different clinical a
Externí odkaz:
https://doaj.org/article/61c4ec0402ba4e588bbc747f4ffab19b
Publikováno v:
Xiehe Yixue Zazhi, Vol 14, Iss 1, Pp 190-195 (2023)
Lynch syndrome (LS), an autosomal dominant genetic disorder caused by mismatch repair gene defects, is characterized by the susceptibility to multi-system malignancies. LS associated endometrial cancer (LS-EC) is the most common extraintestinal senti
Externí odkaz:
https://doaj.org/article/c4bf80f164c141a1b436e6070cd8b319
Publikováno v:
Global Medical Genetics, Vol 10, Iss 01, Pp 001-005 (2023)
Background Lynch syndrome (LS) is an autosomal dominant condition due to the germline mutation in the mismatch repair (MMR) genes including MLH1, MSH2, MSH6, and PMS2 (post-meiotic segregation increased 2). The MMR mutation carriers have high risk fo
Externí odkaz:
https://doaj.org/article/ff247c6dc8c14d4596d3d1046332de02
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
InstructionLynch syndrome (LS) is the most common inherited cancer predisposition disorder of colorectal cancer (CRC) which is associated with pathogenic variants in 4 mismatch repair (MMR) genes. Here, we reported a multi-generation Chinese family c
Externí odkaz:
https://doaj.org/article/84892684aaf747d6a72970fa35b3e5a0
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