Inhibition of miR-22 enhanced the efficacy of icotinib plus pemetrexed in a rat model of non-small cell lung cancer

Autor: Jing Zhang, Zhi-Qiang Xue, Bin Wang, Jia-Xin Wen, Yun-Xi Wang

Publikováno v: Iranian Journal of Basic Medical Sciences, Vol 23, Iss 3, Pp 329-336 (2020)

Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with H

Externí odkaz: https://doaj.org/article/3a8dc8a803554bdb84438c2360744b01

The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p

Autor: Giulia Soldà, Michela Deleidi, Stefano Goldwurm, Valeria Rimoldi, Rosanna Asselta, Maura Samarani, Massimo Aureli, Alessio Di Fonzo, Letizia Straniero, Rejko Krüger, Stefano Duga

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific reports, 7(1), 12702. England (2017).
Scientific Reports
Scientific reports 7(1), 12702 (2017). doi:10.1038/s41598-017-12973-5

Mutations in the GBA gene, encoding lysosomal glucocerebrosidase, represent the major predisposing factor for Parkinson’s disease (PD), and modulation of the glucocerebrosidase activity is an emerging PD therapy. However, little is known about mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b578116239757fa0851e0f9df3a6242
http://link.springer.com/article/10.1038/s41598-017-12973-5