Zobrazeno 1 - 10
of 404
pro vyhledávání: '"mir-15a"'
Publikováno v:
Renal Failure, Vol 46, Iss 1 (2024)
Vascular calcification (VC) is highly prevalent in patients undergoing hemodialysis, and is a significant contributor to the mortality rate. Therefore, biomarkers that can accurately predict the onset of VC are urgently required. Our study aimed to i
Externí odkaz:
https://doaj.org/article/603432334ee548509eaa4f0455c64b02
Autor:
Francesca Romana Liberati, Sara Di Russo, Lorenzo Barolo, Giovanna Peruzzi, Maria Vittoria Farina, Sharon Spizzichino, Federica Di Fonzo, Deborah Quaglio, Luca Pisano, Bruno Botta, Alessandra Giorgi, Alberto Boffi, Francesca Cutruzzolà, Alessio Paone, Paola Baiocco
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 402 (2024)
Chronic lymphocytic leukemia (CLL) is a widespread type of leukemia that predominantly targets B lymphocytes, undermining the balance between cell proliferation and apoptosis. In healthy B cells, miR-15/16, a tandem of microRNAs, functions as a tumor
Externí odkaz:
https://doaj.org/article/c3cb26ae36b04029a7e08117175fdbb3
Autor:
Tatiane Vieira Braga, Fernanda Cristina Gontijo Evangelista, Marie Gabriele Santiago, Aline Lúcia Menezes Ferrão, Tamara Dauare de Almeida, Bárbara Lima da Fonseca Barbosa, Sergio Schusterschitz da Silva Araujo, Glaciano Nogueira Ribeiro, Maria das Graças Carvalho, Adriano de Paula Sabino
Publikováno v:
Brazilian Journal of Pharmaceutical Sciences, Vol 58 (2022)
Abstract Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16- 1, ZAP-70, and Ang-2 by qPCR, as well as the plasma levels of B
Externí odkaz:
https://doaj.org/article/c394db9c4b9d453b96f579f57e338f0e
Autor:
Noha Hamdy Eltaweel, Ghada Youssef ElKamah, Rabab Khairat, Hanan Abd Elmawgoud Atia, Khalda S. Amr
Publikováno v:
Journal of Genetic Engineering and Biotechnology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Fetal hemoglobin (HbF) induction has shown promise for the treatment of β-hemoglobinopathies. HbF induction in β-thalassemia could overcome ineffective hematopoiesis and thus terminate transfusion dependency for formerly transfu
Externí odkaz:
https://doaj.org/article/00819864096e44f385d25859494fe326
Autor:
Sadeghzadeh S, Dehghani Ashkezari M, Seifati SM, Vahidi Mehrjardi MY, Dehghan Tezerjani M, Ladan SAB
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 13, Pp 3461-3469 (2020)
Salman Sadeghzadeh,1 Mahmood Dehghani Ashkezari,1 Seyed Morteza Seifati,1 Mohammad Yahya Vahidi Mehrjardi,2,3 Masoud Dehghan Tezerjani,4 Sara Sadeghzadeh,5 Seyed Amir Behtash Ladan1 1Medical Biotechnology Research Center, Ashkezar Branch, Islamic Aza
Externí odkaz:
https://doaj.org/article/aee9ace69b804bd1a6808cec9382cb71
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-15 (2020)
Abstract Background We focused on the KCNQ1OT1/miR-15a/PD-L1 axis and explored its significance in regulating immune evasion and malignant behaviors of prostate cancer (PC) cells. Methods The expression levels of KCNQ1OT1, miR-15a, PD-L1, and CD8 in
Externí odkaz:
https://doaj.org/article/ac981835951f4b45bdd6f17e78725ca9
Publikováno v:
Guoji Yanke Zazhi, Vol 20, Iss 6, Pp 999-1002 (2020)
miRNA-15a(miR-15a)is a non-coding small molecule RNA located on 13q14 gene. It affects the growth, development, differentiation and apoptosis of all organs and cells of the whole body. As the study progressively deepened, it was found that the role o
Externí odkaz:
https://doaj.org/article/35774a4d59e742c9bceb438e95384b64
Autor:
Jie‐Jie Hu, Li‐Jun Qin, Zhi‐Yan Liu, Pei Liu, Hai‐Ping Wei, Hao‐Yue Wang, Chong‐Chong Zhao, Zhao‐Ming Ge
Publikováno v:
Kaohsiung Journal of Medical Sciences, Vol 36, Iss 1, Pp 27-34 (2020)
Abstract Multiple microRNAs (miRs) have also been implicated in ischemic brain injury. This research intended to probe the regulatory function and the mechanism of miR‐15a on the ischemic brain injury induced by oxygen‐glucose deprivation/reoxyge
Externí odkaz:
https://doaj.org/article/9ea3fa5a73084e86a464af053b17f978
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 1815-1822 (2019)
Thyroid cancer is widely diagnosed as malignancy in endocrine system. This study attempted to validate UCA1 possessed modulatory function on cell proliferation and epithelial mesenchymal transition (EMT) in human thyroid cancer cell line TPC-1. Ectop
Externí odkaz:
https://doaj.org/article/7e080b64aae2451d869d654f0b8e4383
Publikováno v:
Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 3188-3193 (2019)
Objective To investigate the effects of miR-15a on proliferation and apoptosis of human knee articular chondrocytes and explore its underlying mechanism.Methods qRT-PCR was used to detect the expression of miR-15a in normal chondrocytes and knee arth
Externí odkaz:
https://doaj.org/article/88b4b1b8e0d84e45ba5c0bbf2ee10929