Zobrazeno 1 - 10 of 41 pro vyhledávání: '"mioflazine"'
2
The Inhibition of Nucleoside Transport in Human Erythrocytes by Mioflazine Analogues
Autor: Irene M. Pirovano, Adriaan P. IJzerman
Publikováno v: Nucleosides and Nucleotides. 10:1177-1179
Kinetic analysis of the transport protein (both influx and efflux), usually performed with radiolabelled nucleosides such as adenosine and uridine, has provided a wealth of information regarding the various kinetic and equilibrium parameters (1).
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3830f172c3b528512f8254473e243563
https://doi.org/10.1080/07328319108047266
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3
Reversed-phase high-performance liquid chromatography for evaluating the lipophilicity of pharmaceutical substances with ionization up to log P(app) = 8
Autor: Bob Wilffert, Klaus Belsner, Martina Pfeifer
Publikováno v: Journal of Chromatography, 629(2), 123-134. ELSEVIER SCIENCE BV
The RP-HPLC determination of drug lipophilicity was evaluated for its potency as a substitute for the determination of log P(Oct-W) values. The relation of log k(w) to log P(app) (= log P(Oct-W) at pH 7.4) is linear for a testset including protonable
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7600146703cbaf1e5ab3110a1948f3e2
https://research.rug.nl/en/publications/08da9fb6-9390-41b9-9855-337b6a7653f1
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4
In vitro models of cardiac ischaemia and the evaluation of the cardioprotective effects of calcium antagonists and other anti-ischaemic drugs
Autor: Hugtenburg, J.G., Beckeringh, J.J., Boddeke, H.W.G.M., Heijnis, J.B., Jap, T.J.W., Mathy, M.-J., Van Zwieten, P.A.
Publikováno v: Progress in Pharmacology and Clinical Pharmacology, 8(2), 19-35
Hugtenburg, J G, Beckeringh, J J, Boddeke, H W G M, Heijnis, J B, Jap, T J W, Mathy, M J & Van Zwieten, P A 1990, ' In vitro models of cardiac ischaemia and the evaluation of the cardioprotective effects of calcium antagonists and other anti-ischaemic drugs ', Progress in Pharmacology and Clinical Pharmacology, vol. 8, no. 2, pp. 19-35 .
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b1908edecb0566a4dbc81153114037ba
https://research.vumc.nl/en/publications/59a2fba9-f623-443e-a824-a89830663490
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5
The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts
Autor: Jacqueline G. Hugtenburg, Jan van Marle, Jan Jacob Beckeringh, Mario J.D. Van Voorst, Marie Jeanne Mathy, Pieter A. Van Zwieten, M. G. C. Hendriks, Henk A. van Veen
Publikováno v: European journal of pharmacology, 178(1), 71-78. Elsevier
European Journal of Pharmacology, 178(1), 71-78. Elsevier
Hugtenburg, J G, Van Voorst, M J D, Van Marle, J, Mathy, M J, Beckeringh, J J, Van Veen, H A, Hendriks, M G C & Van Zwieten, P A 1990, ' The influence of nifedipine and mioflazine on mitochondrial calcium overload in normoxic and ischaemic guinea-pig hearts ', European Journal of Pharmacology, vol. 178, no. 1, pp. 71-78 . https://doi.org/10.1016/0014-2999(90)94794-X
The influence of nifedipine (20 nM) and mioflazine (300 nM), i.e. concentrations inducing a 60–70% recovery of cardiac function during reperfusion of globally ischaemic guinea-pig working beans, on the mitochondrial calcium content was investigated
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac79c1b171829bdbae0c7e94111e315f
https://pure.amc.nl/en/publications/the-influence-of-nifedipine-and-mioflazine-on-mitochondrial-calcium-overload-in-normoxic-and-ischaemic-guineapig-hearts(5b989b72-dc98-4906-8758-f44df68bf5d7).html
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6
[3H]R75231; A New Radiolabelled Nucleoside Transporter Probe Related to Mioflazine and Lidoflazine
Autor: Ad P. IJzerman, Marieke Kruidering, H. Van Belle
Publikováno v: Nucleosides and Nucleotides. 10:1223-1224
The transport of nucleosides and analogues across the plasma membrane of animal cells is mediated by nucleoside-specific transport proteins, by means of facilitated diffusion. Development of highly potent tritiated transport inhibitors allowed ligand
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070a1acbc22869f8a5237de66d93ab0b
https://doi.org/10.1080/07328319108047285
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7
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10
Evaluation of protective effects of lidoflazine and mioflazine in cardiac ischemia
Autor: Guo-Shu Liu, Marcel Borgers, R. Xhonneux, Fred Thoné, Luc Wouters, Patrick van Overloop, Lambert Leijssen
Publikováno v: Drug Development Research. 8:407-416
The protective effects of lidoflazine and mioflazine against normothermic ischemia were evaluated in isolated rabbit hearts used in the working mode. Pretreatment with 0.125 mg\liter of these drugs improved recovery of cardiodynamic function during p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::553d61852accdc72e5367a370e1e9761
https://doi.org/10.1002/ddr.430080147
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