Zobrazeno 1 - 10
of 1 873
pro vyhledávání: '"minicircle"'
Autor:
Anna Czarnota, Aleksandra Raszplewicz, Aleksandra Sławińska, Krystyna Bieńkowska-Szewczyk, Katarzyna Grzyb
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract An effective vaccine against hepatitis C virus (HCV) should elicit both humoral and cellular immune responses. Previously, we characterized a bivalent vaccine candidate against hepatitis B (HBV) and HCV using chimeric HBV-HCV virus-like part
Externí odkaz:
https://doaj.org/article/e58c8607661f46729300de9c013429c3
Autor:
Chaopin Yang, Jinqi You, Qiuzhong Pan, Yan Tang, Liming Cai, Yue Huang, Jiamei Gu, Yizhi Wang, Xinyi Yang, Yufei Du, Dijun Ouyang, Hao Chen, Haoran Zhong, Yongqiang Li, Jieying Yang, Yulong Han, Fengze Sun, Yuanyuan Chen, Qijing Wang, Desheng Weng, Zhongqiu Liu, Tong Xiang, Jianchuan Xia
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-19 (2023)
Abstract Background CD133 is considered a marker for cancer stem cells (CSCs) in several types of tumours, including hepatocellular carcinoma (HCC). Chimeric antigen receptor-specific T (CAR-T) cells targeting CD133-positive CSCs have emerged as a to
Externí odkaz:
https://doaj.org/article/10923eba8c51443a882b030449ddfcf7
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Although more than 10% of the human genome has the potential to fold into non-B DNA, the formation of non-canonical structural motifs as part of long dsDNA chains are usually considered as unfavorable from a thermodynamic point of view. However, rece
Externí odkaz:
https://doaj.org/article/0c4f3a64abad4508b321ea8766115d7b
Autor:
James A. Williams, Patrick A. Paez
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 494-503 (2023)
The cell and gene therapy industry has employed the same plasmid technology for decades in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA production. While canonical plasmids contain antibiotic resistance markers in
Externí odkaz:
https://doaj.org/article/328a004e2bb244c38b6637ccf2167d91
Autor:
Pornchai Anuntasomboon, Suradej Siripattanapipong, Sasimanas Unajak, Kiattawee Choowongkomon, Richard Burchmore, Saovanee Leelayoova, Mathirut Mungthin, Teerasak E-kobon
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-14 (2022)
Abstract Background The mitochondrial DNA of trypanosomatids, including Leishmania, is known as kinetoplast DNAs (kDNAs). The kDNAs form networks of hundreds of DNA circles that are evidently interlocked and require complex RNA editing. Previous stud
Externí odkaz:
https://doaj.org/article/c7bdb8df825b4243b2935da345aa0527
Autor:
Sereina Deplazes, Andrea Schlegel, Zhuolun Song, Gabriella Allegri, Nicole Rimann, Tanja Scherer, Melanie Willimann, Lennart Opitz, Sharon C. Cunningham, Ian E. Alexander, Anja Kipar, Johannes Häberle, Beat Thöny, Hiu Man Grisch-Chan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 352-367 (2022)
Hydrodynamic tail vein injection (HTV) is the “gold standard” for delivering naked DNA vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes. While HTV corrects metabolic liver defects such as phenylketonuria or cystat
Externí odkaz:
https://doaj.org/article/334928f0d4ad4afba5bcb442c5af482b
Akademický článek
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Akademický článek
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Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 162-175 (2022)
Decoy technology is a versatile and specific DNA oligonucleotide-based targeting strategy of pathogenic transcription factors (TFs). Chemical modifications of linear decoy oligonucleotides have been made to decrease nuclease sensitivity because of th
Externí odkaz:
https://doaj.org/article/25ce9cf87b3848e2b18fbde3bedfc7f2
Autor:
Sun Woo Lim, Yoo Jin Shin, Sheng Cui, Eun Jeong Ko, Seok Ho Yoo, Byung Ha Chung, Chul Woo Yang
Publikováno v:
The Korean Journal of Internal Medicine, Vol 37, Iss 5, Pp 1031-1049 (2022)
Background/Aims We previously proposed minicircle vector technology as the potential platform for the development and production of new biologics. In this study, we have designed a novel target molecule for the treatment of allograft rejection and ev
Externí odkaz:
https://doaj.org/article/18057ddfa09c4856b77d4effd55a0823