Výsledky vyhledávání - "mini G protein"

Akademický článek

Current applications of mini G proteins to study the structure and function of G protein-coupled receptors

Autor: Byron Carpenter

Publikováno v: AIMS Bioengineering, Vol 5, Iss 4, Pp 209-225 (2018)

G protein-coupled receptors (GPCRs) regulate intracellular signalling pathways that contribute to virtually all aspects of cell function. Characterising GPCRs in each of their conformational states is key to understanding their mechanism of action, b

Externí odkaz: https://doaj.org/article/dc8427e9951c47b7af1730ad61c1f5ed

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Akademický článek

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

Autor: Javier García-Nafría, Yang Lee, Xiaochen Bai, Byron Carpenter, Christopher G Tate

Publikováno v: eLife, Vol 7 (2018)

The adenosine A2A receptor (A2AR) is a prototypical G protein-coupled receptor (GPCR) that couples to the heterotrimeric G protein GS. Here, we determine the structure by electron cryo-microscopy (cryo-EM) of A2AR at pH 7.5 bound to the small molecul

Externí odkaz: https://doaj.org/article/8d680e6ec950444e8faa3bf12c4f8e4a

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A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

Autor: Höring, Carina, Seibel, Ulla, Tropmann, Katharina, Grätz, Lukas, Mönnich, Denise, Pitzl, Sebastian, Bernhardt, Günther, Pockes, Steffen, Strasser, Andrea

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8440, p 8440 (2020)

In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of GPCR-G protein interactions and G protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c2a45d58cbfad92ffecaf866ba3b4
https://epub.uni-regensburg.de/44212/

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Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

Autor: Qingwen Wan, Christopher G. Tate, Rony Nehmé, Najeah Okashah, Byron Carpenter, Asuka Inoue, Nevin A. Lambert

Publikováno v: The Journal of Biological Chemistry

G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e9aed8996e8becdb07d861e0d3a90
https://doi.org/10.1074/jbc.ra118.001975

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Akademický článek

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Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation

Autor: Christopher G. Tate, Byron Carpenter

Publikováno v: Protein Engineering, Design and Selection

G protein-coupled receptors (GPCRs) modulate cytoplasmic signalling in response to extracellular stimuli, and are important therapeutic targets in a wide range of diseases. Structure determination of GPCRs in all activation states is important to elu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2010c995144b89fb03268b5c0ea93b

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