Výsledky vyhledávání - "mini G protein"

A Dynamic, Split-Luciferase-Based Mini-G Protein Sensor to Functionally Characterize Ligands at All Four Histamine Receptor Subtypes

Autor: Höring, Carina, Seibel, Ulla, Tropmann, Katharina, Grätz, Lukas, Mönnich, Denise, Pitzl, Sebastian, Bernhardt, Günther, Pockes, Steffen, Strasser, Andrea

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8440, p 8440 (2020)

In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of GPCR-G protein interactions and G protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5c2a45d58cbfad92ffecaf866ba3b4
https://epub.uni-regensburg.de/44212/

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Mini G protein probes for active G protein–coupled receptors (GPCRs) in live cells

Autor: Qingwen Wan, Christopher G. Tate, Rony Nehmé, Najeah Okashah, Byron Carpenter, Asuka Inoue, Nevin A. Lambert

Publikováno v: The Journal of Biological Chemistry

G protein–coupled receptors (GPCRs) are key signaling proteins that regulate nearly every aspect of cell function. Studies of GPCRs have benefited greatly from the development of molecular tools to monitor receptor activation and downstream signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e9aed8996e8becdb07d861e0d3a90
https://doi.org/10.1074/jbc.ra118.001975

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Akademický článek

Expression, Purification and Crystallisation of the Adenosine A2A Receptor Bound to an Engineered Mini G Protein

Autor: Byron Carpenter, Christopher Tate

Publikováno v: Bio-Protocol, Vol 7, Iss 8 (2017)

G protein-coupled receptors (GPCRs) promote cytoplasmic signalling by activating heterotrimeric G proteins in response to extracellular stimuli such as light, hormones and nucleosides. Structure determination of GPCR–G protein complexes is central

Externí odkaz: https://doaj.org/article/8a97e72901bf4c498d52ae94be1528bc

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Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2a Receptor by a Mini-G Protein

Autor: Gilles Labesse, Nicolas Floquet, Maxime Louet, Pedro Renault, Jacky Marie

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-41980-x⟩

Through their coupling to G proteins, G Protein-Coupled Receptors (GPCRs) trigger cellular responses to various signals. Some recent experiments have interestingly demonstrated that the G protein can also act on the receptor by favoring a closed conf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a3f6be182b48adfd82568e6ef4ce58
http://europepmc.org/articles/PMC6445292

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Akademický článek

Expression, Purification and Crystallisation of the Adenosine A 2A Receptor Bound to an Engineered Mini G Protein.

Autor: Carpenter B; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, UK., Tate CG; MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, UK.

Publikováno v: Bio-protocol [Bio Protoc] 2017 Apr 20; Vol. 7 (8).

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