Zobrazeno 1 - 10
of 1 426
pro vyhledávání: '"mimotope"'
Autor:
Xiaokun Zhang, Ye Wu, Jiayi Lin, Shengxin Lu, Xinchen Lu, Aoyu Cheng, Hongzhuan Chen, Weidong Zhang, Xin Luan
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 3818-3833 (2024)
Immunotherapies hold immense potential for achieving durable potency and long-term survival opportunities in cancer therapy. As vital biological mediators, peptides with high tissue penetration and superior selectivity offer significant promise for e
Externí odkaz:
https://doaj.org/article/4e96d6cb0559410681783ee1a600fbe2
Autor:
Jiawen Yang, Aixuan Zhou, Minyi Li, Qiaoxian He, Jingwei Zhou, Jacques Crommen, Wentao Wang, Zhengjin Jiang, Qiqin Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1317-1328 (2024)
Due to low immobilized ligand density, limited binding capacity, and severe interference from serum proteins, developing ideal peptide-based biomaterials for precise recognition and in vivo analysis of biopharmaceuticals remains a huge challenge. In
Externí odkaz:
https://doaj.org/article/462faa344e4940e5989c9b5d2eab206d
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
ABSTRACTMimotope, a kind of peptide vaccine, is developed to bind natural receptor and inhibit the downstream signaling. We have demonstrated that the vaccination of Tocilizumab mimotopes could alleviate the renal fibrosis by interfering with both IL
Externí odkaz:
https://doaj.org/article/2a63ffc043034fcba61cea339f955bfc
Autor:
Rang Li, Sabrina Wilderotter, Madison Stoddard, Debra Van Egeren, Arijit Chakravarty, Diane Joseph-McCarthy
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Introduction: A fundamental challenge in computational vaccinology is that most B-cell epitopes are conformational and therefore hard to predict from sequence alone. Another significant challenge is that a great deal of the amino acid sequence of a v
Externí odkaz:
https://doaj.org/article/ea77786d346d4f2ba5cfe2a0a4f4dcb1
Publikováno v:
Basic and Clinical Andrology, Vol 32, Iss 1, Pp 1-11 (2022)
Résumé Contexte À ce jour, il n'existe pas de méthodes normalisées de préparation d'antigènes spermatiques pour la détection des anticorps anti-spermatozoïdes (ACAS). Dans le but d’élaborer un tel test ELISA (enzyme-linked immunosorbent a
Externí odkaz:
https://doaj.org/article/2f82e27572d648289c14e47b88cd5273
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Porcine epidemic diarrhea virus (PEDV) is the causative agent of a highly contagious enteric disease of pigs characterized by diarrhea, vomiting, and severe dehydration. PEDV infects pigs of all ages, but neonatal pigs during the first week of life a
Externí odkaz:
https://doaj.org/article/d040cf1d34424ee1aac4a634a472c2da
Autor:
Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong H. Kang, Nishant K. Singh, Brooke D. Huisman, C. Garrett Rappazzo, Kelly D. Moynihan, Laura Maiorino, Connor S. Dobson, Taeyoon Kyung, Khloe S. Gordon, Patrick V. Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, K. Dane Wittrup, Darrell J. Irvine, Michael E. Birnbaum
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
While immune checkpoint blockade results in durable responses for some patients, many others have not experienced such benefits. These treatments rely upon reinvigorating specific T cell-antigen interactions. However, it is often unknown what antigen
Externí odkaz:
https://doaj.org/article/974ae2fd3083480d86e6565189e0552e
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1233-1239 (2020)
Vascular Endothelial Growth Factor (VEGF) promotes angiogenesis in tumours of various cancers. Monoclonal antibodies and nanobodies are one of the potent agents in the treatment of cancer. Due to their high costs, researchers are considering to desig
Externí odkaz:
https://doaj.org/article/8eaa4266dc2b4c10951201809fd54bcd