A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death, gliosis, and electroretinogram distortion in male rats subjected to perinatal asphyxia

Autor: Manuel Rey-Funes, Juan Carlos Fernández, Rafael Peláez, Manuel Soliño, Daniela S. Contartese, Nicolás S. Ciranna, Ronan Nakamura, Aníbal Sarotto, Verónica B. Dorfman, José M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Juan José López-Costa, Ignacio M. Larrayoz, Alfredo Martínez, César Fabián Loidl

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Perinatal asphyxia (PA) represents a major problem in perinatology and may cause visual losses, including blindness. We, and others, have shown that hypothermia prevents retinal symptoms associated to PA. In the present work, we evaluat

Externí odkaz: https://doaj.org/article/818fe5c6e2d848c8ac00bd1381d23422

A hypothermia mimetic molecule (zr17-2) reduces ganglion cell death and electroretinogram distortion in a rat model of intraorbital optic nerve crush (IONC)

Autor: Daniela S. Contartese, Manuel Rey-Funes, Rafael Peláez, Manuel Soliño, Juan C. Fernández, Ronan Nakamura, Nicolás S. Ciranna, Aníbal Sarotto, Verónica B. Dorfman, Juan J. López-Costa, José M. Zapico, Ana Ramos, Beatriz de Pascual-Teresa, Ignacio M. Larrayoz, César F. Loidl, Alfredo Martínez

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

Introduction: Ocular and periocular traumatisms may result in loss of vision. Our previous work showed that therapeutic hypothermia prevents retinal damage caused by traumatic neuropathy. We also generated and characterized small molecules that elici

Externí odkaz: https://doaj.org/article/c3692b7a46e34c249641c84f1b254f08

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Brilacidin, a Non-Peptide Defensin-Mimetic Molecule, Inhibits SARS-CoV-2 Infection by Blocking Viral Entry.

Autor: Xu C; Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA., Wang A; Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA., Honnen W; Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA., Pinter A; Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA., Weston WK; Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA., Harness JA; Innovation Pharmaceuticals, Inc., Wakefield, Massachusetts, USA., Narayanan A; National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, Virginia, USA., Chang TL; Public Health Research Institute, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.; Department of Microbiology, Biochemistry and Molecular Genetics, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA.

Publikováno v: EC microbiology [EC Microbiol] 2022 Apr; Vol. 18 (4), pp. 1-12. Date of Electronic Publication: 2022 Mar 08.

In silico binding analysis of human CD40 ligand mimetic molecule, 3-(dimethylamino)-1-phenyl-1-propanone hydrochloride (3-DPH), with CD40 receptor molecules of various mammalian species

Autor: S. Nagavignesh, M. Sivanandham, S. Sivagami, R. Rathna, N.V. Ghone

Publikováno v: Journal of Environmental Biology. 42:186-191

Aim: To investigate the binding of human CD40 ligand (CD40L) mimetic molecule, 3-(dimethylamino)-1-phenyl-1-propanone hydrochloride (3-DPH), with CD40 receptor (CD40R) molecules of Homo sapiens, Cavia porcellus, Cricetulus griseus, Macaca mulatta, Mu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e5febb061aa9aa273a0711180deddb7
https://doi.org/10.22438/jeb/42/2/mrn-1440