Apparent “mild depolarization of the inner mitochondrial membrane” as a result of a possible generation of the outer membrane potential

Autor: Lemeshko, Victor V.

Publikováno v: In BBA - Biomembranes 1 November 2022 1864(11)

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program

Autor: Alisa A. Panteleeva, Thomas B. Hildebrandt, O. A. Averina, Vladimir P. Skulachev, Mikhail Yu. Vyssokikh, Roman A. Zinovkin, Nicolas Fasel, Fedor F. Severin, Konstantin G. Lyamzaev, M. V. Marey, Susanne Holtze, Maxim V. Skulachev

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 117(12):6491-6501
Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 12, pp. 6491-6501

Significance The mitochondria, organelles that produce the largest amounts of ATP and reactive oxygen species (mROS) in living cells, are equipped with a universal mechanism that can completely prevent mROS production. This mechanism consists of mild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f267a8d977cf1edb336ec301038aa522
https://doi.org/10.1073/pnas.1916414117

Apparent 'mild depolarization of the inner mitochondrial membrane' as a result of a possible generation of the outer membrane potential

Autor: Victor V. Lemeshko

Publikováno v: Biochimica et biophysica acta. Biomembranes. 1864(11)

Recently reported kinase-linked mild depolarization of mitochondria, which prevents the generation of the reactive oxygen species (ROS) and disappears in various organs of the old mice, has been assumed to represent a crucial component of the mitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5c9d2c15d1f0fdc5555b0f7eb344ef
https://pubmed.ncbi.nlm.nih.gov/35985076

Mild depolarization of the inner mitochondrial membrane is a crucial component of the mechano-chemiosmotic mechanism of coupling

Autor: Ruslan E. Kasumov, Irina V. Kasumova, Eldar A. Kasumov

Publikováno v: Journal of Novel Physiotherapy and Physical Rehabilitation. 7:033-035

The human body receives the main energy in the form of ATP (about 50 kg per day), mainly by oxidative phosphorylation in the mitochondria, and a small part from glycolysis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c9b09a8389b0f4ec450968c8284d66c
https://doi.org/10.17352/2455-5487.000075

Mild depolarization is involved in troglitazone-induced liver mitochondrial membrane permeability transition via mitochondrial iPLA

Autor: Tomoyuki, Sato, Masahiro, Segawa, Shuichi, Sekine, Kousei, Ito

Publikováno v: The Journal of toxicological sciences. 44(11)

Troglitazone, the first peroxisome proliferator-associated receptor γ agonist developed as an antidiabetic drug, was withdrawn from the market due to idiosyncratic severe liver toxicity. One proposed mechanism by which troglitazone causes liver inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8b48c4a91ba092b3d42a8480ab0fab19
https://pubmed.ncbi.nlm.nih.gov/31708537