A Brighton collaboration standardized template with key considerations for a benefit/risk assessment for a viral vector vaccine based on a non-replicating modified vaccinia virus Ankara viral vector.

Autor: Link EK; Ludwig-Maximilians-University Munich (LMU Munich), Department of Veterinary Sciences, Division of Virology, Oberschleißheim, Germany., Tscherne A; Ludwig-Maximilians-University Munich (LMU Munich), Department of Veterinary Sciences, Division of Virology, Oberschleißheim, Germany., Sutter G; Ludwig-Maximilians-University Munich (LMU Munich), Department of Veterinary Sciences, Division of Virology, Oberschleißheim, Germany., Smith ER; Brighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA. Electronic address: bc-coordinator@taskforce.org., Gurwith M; Brighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA., Chen RT; Brighton Collaboration, A Program of the Task Force for Global Health, Decatur, GA, USA., Volz A; University of Veterinary Medicine Hannover, Institute of Virology, Hannover, Germany.

Publikováno v: Vaccine [Vaccine] 2025 Jan 01; Vol. 43 (Pt 1), pp. 126521. Date of Electronic Publication: 2024 Nov 28.

Structural basis of main proteases of MERS-CoV bound to antineoplastic drug carmofur.

Autor: Guo L; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China., Zeng P; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China., Zhou X; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China., Li W; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China., Zhang J; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China. Electronic address: zhangxiaokong@hotmail.com., Li J; Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China; Jiangxi Jmerry Biopharmaceutical Co., Ltd., Ganzhou, China. Electronic address: rmsl_2040@163.com.

Publikováno v: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Nov 26; Vol. 735, pp. 150469. Date of Electronic Publication: 2024 Jul 29.

Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.

Autor: Kerr CM; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., Pfannenstiel JJ; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., Alhammad YM; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., O'Connor JJ; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., Ghimire R; Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, USA., Shrestha R; Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, USA., Khattabi R; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., Saenjamsai P; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., Parthasarathy S; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA., McDonald PR; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA., Gao P; Protein Production Group, University of Kansas, Lawrence, Kansas, USA., Johnson DK; Molecular Graphics and Modeling Laboratory and the Computational Chemical Biology Core, University of Kansas, Lawrence, Kansas, USA., More S; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA.; Oklahoma Center for Respiratory and Infectious Diseases, College of Veterinary Medicine, Stillwater, Oklahoma, USA., Roy A; High Throughput Screening Laboratory, University of Kansas, Lawrence, Kansas, USA., Channappanavar R; Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, Oklahoma, USA.; Oklahoma Center for Respiratory and Infectious Diseases, College of Veterinary Medicine, Stillwater, Oklahoma, USA., Fehr AR; Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.

Publikováno v: Journal of virology [J Virol] 2024 Nov 19; Vol. 98 (11), pp. e0131324. Date of Electronic Publication: 2024 Oct 10.

Coronavirus nucleocapsid-based vaccine provides partial protection against hetero-species coronavirus in murine models.

Autor: Lee P; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; University of Science and Technology (UST), Daejeon, South Korea., Kim J; Chungnam National University College of Veterinary Medicine, Daejeon, South Korea., Oh H; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; Chungbuk National University College of Veterinary Medicine, Cheongju, South Korea., Kim CU; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea., Jeong AY; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; Princeton University, Princeton, NJ, USA., Lee MS; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; University of Science and Technology (UST), Daejeon, South Korea., Jang MS; Korea Institute of Toxicology, Daejeon, South Korea., Hong JJ; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea. Electronic address: hong75@kribb.re.kr., Park JE; Chungnam National University College of Veterinary Medicine, Daejeon, South Korea. Electronic address: jepark@cnu.ac.kr., Kim DJ; Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea; Chungbuk National University College of Medicine, Cheongju, South Korea; Biomedical Research Institute, Chungbuk National University Hospital, Cheongju, South Korea. Electronic address: golddj@cbnu.ac.kr.

Publikováno v: Antiviral research [Antiviral Res] 2024 Nov; Vol. 231, pp. 105991. Date of Electronic Publication: 2024 Aug 23.

Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV.

Autor: Chao CW; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Miranda MC; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Catanzaro NJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Hubbard ML; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Addetia A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Brown JT; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Dosey A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Valdez A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Hendricks GG; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Ahlrichs M; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Dobbins C; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Hand A; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., McGowan J; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Simmons B; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Treichel C; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Willoughby I; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., McGuire AT; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle WA 98115, USA., Leaf EM; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Baric RS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Howard Hughes Medical Institute, Seattle, WA 98195, USA., King NP; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: neilking@uw.edu.

Publikováno v: Cell reports [Cell Rep] 2024 Dec 24; Vol. 43 (12), pp. 115036. Date of Electronic Publication: 2024 Dec 06.