Zobrazeno 1 - 10
of 508
pro vyhledávání: '"microtubule severing"'
Autor:
Şirin Korulu
Publikováno v:
Trakya University Journal of Natural Sciences, Vol 25, Iss 2, Pp 197-201 (2024)
Microtubules (MT), essential elements of the cytoskeleton have important roles in the cell such as intracellular cargo transport, cell motility and cell division. They provide support, growth and maintenance of the axonal and dendritic processes in n
Externí odkaz:
https://doaj.org/article/8441a79f286c4532a8f6dbde5feb6dd3
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Hereditary spastic paraplegia (HSP) is a rare genetically heterogeneous neurodegenerative disorder. The most common type of HSP is caused by pathogenic variants in the SPAST gene. Various hypotheses regarding the pathogenic mechan
Externí odkaz:
https://doaj.org/article/c41d8fbefd9e4596bb32d817d179eef3
Autor:
Jie Yang, Yunlong Zhang, Zhenbin Cai, Jianyu Zou, Shaojin Li, Guiqiang Miao, Hongsheng Lin, Xiaodong Zhao, Minghui Tan
Publikováno v:
Brain Research Bulletin, Vol 205, Iss , Pp 110806- (2023)
Promoting axonal regeneration is an effective strategy for recovery from traumatic spinal cord injury (SCI). Spastin, a microtubule-severing protein, modulates axonal outgrowth and branch formation by regulating microtubule dynamics. However, the exa
Externí odkaz:
https://doaj.org/article/fc61acd6f9de4433a6ec1490d9fd52fc
Akademický článek
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Akademický článek
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Akademický článek
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Publikováno v:
European Journal of Histochemistry, Vol 67, Iss 1 (2023)
Spastin, a microtubule-severing enzyme, is known to be important for neurite outgrowth. However, the role of spastin post-translational modification, particularly its phosphorylation regulation in neuronal outgrowth, remains unclear. This study aimed
Externí odkaz:
https://doaj.org/article/e2d4ae9bf0a44d68b4ceedf5486536b6
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mount
Externí odkaz:
https://doaj.org/article/f09102228feb460a963fb2d1446520b8
Autor:
K. Alice Lindsay, Nedine Abdelhamid, Shehani Kahawatte, Ruxandra I. Dima, Dan L. Sackett, Tara M. Finegan, Jennifer L. Ross
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 620 (2023)
In cells, microtubule location, length, and dynamics are regulated by a host of microtubule-associated proteins and enzymes that read where to bind and act based on the microtubule “tubulin code,” which is predominantly encoded in the tubulin car
Externí odkaz:
https://doaj.org/article/f260f81c34f1431393245dfd0b1b1081
Publikováno v:
Quantitative Plant Biology, Vol 3 (2022)
Microtubule severing by katanin plays key roles in generating various array patterns of dynamic microtubules, while also responding to developmental and environmental stimuli. Quantitative imaging and molecular genetic analyses have uncovered that dy
Externí odkaz:
https://doaj.org/article/18cda14c29404d13ac8b8d29b2b8c48a