Výsledky vyhledávání - "microtubule catastrophe"

Rescuing microtubules from the brink of catastrophe: CLASPs lead the way

Autor: Elizabeth J. Lawrence, Marija Zanic

Publikováno v: Current Opinion in Cell Biology. 56:94-101

Microtubules are cytoskeletal polymers that dynamically remodel to perform essential cellular functions. Individual microtubules alternate between phases of growth and shrinkage via sudden transitions called catastrophe and rescue, driven by losing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac157dd036cb85d349f9139eaf543412
https://doi.org/10.1016/j.ceb.2018.10.011

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XMAP215 promotes microtubule catastrophe by disrupting the growing microtubule end

Autor: Veronica Farmer, Goker Arpag, Marija Zanic, Sarah L Hall

Publikováno v: The Journal of cell biology. 220(10)

The GTP-tubulin cap is widely accepted to protect microtubules against catastrophe. The GTP-cap size is thought to increase with the microtubule growth rate, presumably endowing fast-growing microtubules with enhanced stability. It is unknown what GT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1c0979a5c1605dc2716f1b330f6a55
https://pubmed.ncbi.nlm.nih.gov/34324632

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Mechanics and Kinetics of Microtubules in Their Environment

Autor: Lee, Cheng-Tai

Microtubules (MTs) are important linear protein filaments which participate in many intracellular physiological processes and provide mechanical support against external compression. The kinetics and mechanics of MTs change rather distinctively in di

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CLASP Mediates Microtubule Repair by Restricting Lattice Damage and Regulating Tubulin Incorporation

Autor: Aher, Amol, Rai, Dipti, Schaedel, Laura, Gaillard, Jeremie, John, Karin, Liu, Qingyang, Altelaar, Maarten, Blanchoin, Laurent, Thery, Manuel, Akhmanova, Anna, Celbiologie, Sub Cell Biology, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Current Biology, 30(11), 2175. Cell Press
Current Biology-CB
Current Biology-CB, 2020, 30 (11), pp.2175-2183. ⟨10.1016/j.cub.2020.03.070⟩
Current Biology
Current Biology-CB, Elsevier, 2020, 30 (11), pp.2175-2183. ⟨10.1016/j.cub.2020.03.070⟩

Summary Microtubules play a key role in cell division, motility, and intracellular trafficking. Microtubule lattices are generally regarded as stable structures that undergo turnover through dynamic instability of their ends [1]. However, recent evid

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https://dspace.library.uu.nl/handle/1874/410286

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The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability

Autor: Szymon W. Manka, Carolyn A. Moores

Publikováno v: Nature structural & molecular biology

Microtubules form from longitudinally and laterally assembling tubulin α/β-dimers. The assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and regrowth. This so-called dynamic instability is governed by GTP hydrolysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dea479511ff06692b7d7b23fe2a6368
http://europepmc.org/articles/PMC6201834

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Regulation of microtubule array in its self-organized dense active crowds*

Autor: Yu-qiang Ma, Xia-qing Shi, Xin-Chen Jiang

Publikováno v: Chinese Physics B. 29:078201

Microtubule self-organization under mechanical and chemical regulations plays a central role in cytokinesis and cellular transportations. In plant-cells, the patterns or phases of cortical microtubules organizations are the direct indicators of cell-

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https://doi.org/10.1088/1674-1056/ab9430

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Human CLASP2 specifically regulates microtubule catastrophe and rescue

Autor: Goker Arpag, Elizabeth J. Lawrence, Marija Zanic, Stephen R. Norris

Publikováno v: Molecular Biology of the Cell

Cytoplasmic linker-associated proteins (CLASPs) are microtubule-associated proteins essential for microtubule regulation in many cellular processes. However, the molecular mechanisms underlying CLASP activity are not understood. Here, we use purified

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https://pubmed.ncbi.nlm.nih.gov/29540526

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Structural effects of cap, crack, and intrinsic curvature on the microtubule catastrophe kinetics

Autor: Cheng-Tai Lee, Eugene M. Terentjev

Publikováno v: The Journal of Chemical Physics. 151:135101

Microtubules (MTs) experience an effect called "catastrophe," which is the transition from the MT growth to a sudden dramatic shrinkage in length. The straight guanosine triphosphate (GTP)-tubulin cap at the filament tip and the intrinsic curvature o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82e55c5b6b4d3bbc318fded21a60483e
https://doi.org/10.1063/1.5122304

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