Zobrazeno 1 - 10
of 643
pro vyhledávání: '"microtissue"'
Autor:
Jan Wolnik, Patrycja Adamska, Aleksandra Oleksy, Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski, Józef Dulak, Monika Biniecka
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects not only the joints but also has significant cardiovascular (CV) manifestations. The mechanistic interplay between RA and cardiovascular complications is not
Externí odkaz:
https://doaj.org/article/2db2a3a2e82c42369e3e8dc261d17dd5
Autor:
I.D. Orge, H. Nogueira Pinto, M.A. Silva, S.J. Bidarra, S.A. Ferreira, I. Calejo, R. Masereeuw, S.M. Mihăilă, C.C. Barrias
Publikováno v:
Bioactive Materials, Vol 38, Iss , Pp 499-511 (2024)
The timely establishment of functional neo-vasculature is pivotal for successful tissue development and regeneration, remaining a central challenge in tissue engineering. In this study, we present a novel (micro)vascularization strategy that explores
Externí odkaz:
https://doaj.org/article/7fc399d7f65d4461a0dd36fa05347132
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
In vivo treatment of rats with phenobarbital (PB) induces liver enzyme induction associated with hepatocyte hypertrophy. In the present study we used a novel microTMA technology coupled with artificial intelligence (AI) driven image analysis and prot
Externí odkaz:
https://doaj.org/article/e8d8f42f4cd447d2ac25a39e8d006d94
Autor:
Sofia Apodaca, Marco Di Salvatore, Arturo Muñoz-Calderón, María de los Ángeles Curto, Silvia A. Longhi, Alejandro G. Schijman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionHuman trophoblastic cell lines, such as BeWo, are commonly used in 2D models to study placental Trypanosoma cruzi infections. However, these models do not accurately represent natural infections. Three-dimensional (3D) microtissue culture
Externí odkaz:
https://doaj.org/article/3d3afaec2b9a4937a5a28fa82eddcd9c
Autor:
Negar Asadollahi, Mohammad Amin Hajari, Mahmoud Alipour Choshali, Mohammad Ajoudanian, Seyed Ali Ziai, Massoud Vosough, Abbas Piryaei
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 421-440 (2024)
Non-alcoholic fatty liver disease (NAFLD) is a high-prevalence and progressive disorder. Due to lack of reliable in vitro models to recapitulate the consecutive phases, the exact pathogenesis mechanism of this disease and approved therapeutic medicat
Externí odkaz:
https://doaj.org/article/7f4c26ede5ed44ba99cdc95377c4a117
Autor:
Thamyris Perez de Souza, Lorraine Martins Rocha Orlando, Leonardo da Silva Lara, Vitoria Barbosa Paes, Lucas Penha Dutra, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Publikováno v:
Molecules, Vol 29, Iss 15, p 3544 (2024)
Chagas disease, a silent but widespread disease that mainly affects a socioeconomically vulnerable population, lacks innovative safe drug therapy. The available drugs, benznidazole and nifurtimox, are more than fifty years old, have limited efficacy,
Externí odkaz:
https://doaj.org/article/404ec5fb989244f89628f9043b63ee64
Publikováno v:
Organoids, Vol 2, Iss 2, Pp 102-119 (2023)
(1) Background: There are no high-throughput microtissue platforms for generating bone marrow micro-ossicles. Herein, we describe a method for the assembly of arrays of microtissues from bone marrow stromal cells (BMSC) in vitro and their maturation
Externí odkaz:
https://doaj.org/article/286154987fcb43ea9bce252b342a2b2b
Autor:
Ou Wang, Li Han, Haishuang Lin, Mingmei Tian, Shuyang Zhang, Bin Duan, Soonkyu Chung, Chi Zhang, Xiaojun Lian, Yong Wang, Yuguo Lei
Publikováno v:
Bioactive Materials, Vol 22, Iss , Pp 518-534 (2023)
Transplanting cell cultured brown adipocytes (BAs) represents a promising approach to prevent and treat obesity (OB) and its associated metabolic disorders, including type 2 diabetes mellitus (T2DM). However, transplanted BAs have a very low survival
Externí odkaz:
https://doaj.org/article/29cb852fcd1a4bad96d4998509e74f76
Autor:
Yuta Kurashina, Keisuke Fukada, Shun Itai, Shuichi Akizuki, Ryo Sato, Akari Masuda, Hidenori Tani, Jun Fujita, Keiichi Fukuda, Shugo Tohyama, Hiroaki Onoe
Publikováno v:
Advanced Science, Vol 10, Iss 35, Pp n/a-n/a (2023)
Abstract In vitro reconstruction of highly mature engineered heart tissues (EHTs) is attempted for the selection of cardiotoxic drugs suitable for individual patients before administration. Mechanical contractile force generated in the EHTs is known
Externí odkaz:
https://doaj.org/article/1d8a0aff19dc4f75a8977fef85d86848
Autor:
Negar Aasadollahei, Niloufar Rezaei, Reihaneh Golroo, Tarun Agarwal, Massoud Vosough, Abbas Piryaei
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 367-391 (2023)
Non-alcoholic fatty liver disease (NAFLD) has become the world’s most common chronic liver disease. However, due to the lack of reliable in vitro NAFLD models, drug development studies have faced many limitations, and there is no food and drug admi
Externí odkaz:
https://doaj.org/article/4dc0b365249e4640988d73e32bc9c1e1