Zobrazeno 1 - 10
of 574
pro vyhledávání: '"microsatellite stable"'
Autor:
Dan Li, Hui Jin, Yan Liu, Jiayin Liu, Xue Zhang, Long Wang, Zhisong Fan, Li Feng, Jing Zuo, Jing Han, Yudong Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
ObjectiveThis study explores the benefits of targeted-immunotherapy combination in third-line or beyond treatment for microsatellite stable (MSS) metastatic colorectal cancer (mCRC) in a real-world setting.MethodsPatients with MSS mCRC who were treat
Externí odkaz:
https://doaj.org/article/96cdba37744c4a77900b327427deea6d
Publikováno v:
Translational Medicine Communications, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Background Immune Checkpoint Inhibitor (ICI) immunotherapy is most effective in immune effector cell infiltrated ‘hot’ tumor lesions, such as occurs in deficient mismatch repair, microsatellite instability high (dMMR/MSI-H) colorectal ca
Externí odkaz:
https://doaj.org/article/428ff7ec15474bee86c5e20ff1b5f8f9
Autor:
Anne Hansen Ree, Eirik Høye, Ying Esbensen, Ann-Christin R. Beitnes, Anne Negård, Linn Bernklev, Linn Kruse Tetlie, Åsmund A. Fretland, Hanne M. Hamre, Christian Kersten, Eva Hofsli, Marianne G. Guren, Halfdan Sorbye, Hilde L. Nilsen, Kjersti Flatmark, Sebastian Meltzer
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
The randomized METIMMOX trial (NCT03388190) examined if patients with previously untreated, unresectable abdominal metastases from microsatellite-stable (MSS) colorectal cancer (CRC) might benefit from potentially immunogenic, short-course oxaliplati
Externí odkaz:
https://doaj.org/article/a08572504c1241d5a365f6b0a359ede1
Autor:
Kanglian Zheng, Xu Zhu, Liang Xu, Guang Cao, Chuanxin Niu, Xiaoluan Yan, Da Xu, Wei Liu, Quan Bao, Lijun Wang, Kun Wang, Baocai Xing, Xiaodong Wang
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Background and aimThe prognosis of microsatellite stable (MSS)-colorectal cancer liver metastasis (CRCLM) following failure of multi-line therapy remains dismal. The aim of this study is to evaluate the efficacy and safety of hepatic arterial infusio
Externí odkaz:
https://doaj.org/article/a140f0ff9a6a44ba9de682271fd62f24
Publikováno v:
Zhongliu Fangzhi Yanjiu, Vol 50, Iss 12, Pp 1227-1231 (2023)
Objective To investigate the clinical efficacy and safety of fruquintinib combined with sintilimab in the treatment of advanced microsatellite stable (MSS) colorectal cancer. Methods A retrospective study of 44 patients with MSS colorectal cancer tre
Externí odkaz:
https://doaj.org/article/7a08ffa028984281ab59549a193d4fcb
Autor:
Menglan Zhai, Zixuan Zhang, Haihong Wang, Jinghua Ren, Sheng Zhang, Mingjie Li, Lichao Liu, Lisha Li, Lan Zhang, Xin Li, Tao Zhang, Zhenyu Lin
Publikováno v:
Cancer Medicine, Vol 13, Iss 1, Pp n/a-n/a (2024)
Abstract Purpose Several studies have demonstrated the effectiveness of anti‐angiogenic drugs in combination with immune checkpoint inhibitors (ICIs) in patients with microsatellite stable (MSS) or mismatch repair proficient (pMMR) metastatic color
Externí odkaz:
https://doaj.org/article/26270b1383f747118ce4203ae7791beb
Autor:
Wensi Zhao, Jun Lei, Shaobo Ke, Yuan Chen, Jiping Xiao, Ze Tang, Li Wang, Yiping Ren, Mohammed Alnaggar, Hu Qiu, Wei Shi, Lei Yin, Yongshun Chen
Publikováno v:
EClinicalMedicine, Vol 66, Iss , Pp 102315- (2023)
Summary: Background: Immunotherapy has revolutionized the treatment of cancer. However, microsatellite stable (MSS) metastatic colorectal cancer (mCRC) shows a low response to PD-1 inhibitors. Antiangiogenic therapy can enhance anti-PD-1 efficacy, bu
Externí odkaz:
https://doaj.org/article/82637cef24b148a3a2c88f91ff67caf0
Autor:
Wen‐Zhuo He, Lei Wang, Chen‐Xi Yin, Jia‐Hong Yi, Ya‐Nan Jin, Chang Jiang, Gui‐Fang Guo, Liang‐Ping Xia
Publikováno v:
Cancer Medicine, Vol 12, Iss 6, Pp 6488-6498 (2023)
Abstract Background Although the use of regorafenib plus nivolumab demonstrates promising outcomes in patients with refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC), this effect has not been substantiated in other studies. M
Externí odkaz:
https://doaj.org/article/c1e64d264da14961962baf3349ed191c
Publikováno v:
Heliyon, Vol 9, Iss 11, Pp e22092- (2023)
Colorectal cancer (CRC) is one of the most common malignancies, and at the initial visit, most patients are diagnosed with metastatic CRC (mCRC). However, immunotherapy is only and highly effective in a very small proportion of patients with mCRC hav
Externí odkaz:
https://doaj.org/article/1e9f42b8b3224d18a2951f785bf92054
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveTo assess the clinical efficacy of neoadjuvant chemoradiotherapy combined with immunotherapy for patients with microsatellite stable (MSS) locally advanced rectal cancer and provide evidence to support clinical decision-making.MethodsA syste
Externí odkaz:
https://doaj.org/article/c89d94c80412494db8a67e0b11fa38c2