Zobrazeno 1 - 10
of 175
pro vyhledávání: '"microsatellite stability"'
Autor:
Rongpu Liang, Dongbing Ding, Yiquan Li, Tianyun Lan, Svetlana Ryabtseva, Shengxin Huang, Jiannan Ren, He Huang, Bo Wei
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Background Immunotherapy for colorectal cancer (CRC) with microsatellite stability (MSS) and mismatch repair proficiency (pMMR) has shown limited success in clinical trials. The combination of immunomodulators and immune checkpoint inhibitor
Externí odkaz:
https://doaj.org/article/1cff8c2587ae464a82811f9555d3891c
Autor:
Cheng Cai, Xia Zhang, Xiaonan Sun, Huogang Wang, Engeng Chen, Li Chen, Benxing Gu, Jianping Wang, Xuefeng Huang, Weifeng Lao, Xiaowei Wang, Min Chen, Shubo Ding, Jinlin Du, Zhangfa Song
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Neoadjuvant chemoradiotherapy followed by total mesorectal excision is a standard treatment for locally advanced rectal cancer. Mismatch repair-deficient locally advanced rectal cancer (LARC) was highly sensitive to PD-1 blockade.
Externí odkaz:
https://doaj.org/article/298fbfc86d9f426ea7c57f5b038fe729
Autor:
William P. Duggan, Batuhan Kisakol, Ina Woods, Mohammedreza Azimi, Heiko Dussmann, Joanna Fay, Tony O’Grady, Barry Maguire, Ian S. Reynolds, Manuela Salvucci, Daniel J. Slade, Deborah A. McNamara, John P. Burke, Jochen H.M. Prehn
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTMucinous colorectal cancer (CRC) is a common histological subtype of colorectal adenocarcinoma, associated with a poor response to chemoradiotherapy. The commensal facultative anaerobes fusobacteria, have been associated with poor prognosis s
Externí odkaz:
https://doaj.org/article/2b11e6dc763e4a1aacdfb8cd8e2a82f3
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Objective MSI has a better prognosis than MSS in colorectal cancer patients, and the main objective of this study was to screen for differentially expressed molecules between MSI and MSS primary colorectal cancers using bioinformatics. Mater
Externí odkaz:
https://doaj.org/article/3a0ad553d56d456393f2d2e1d4b1dcb6
Publikováno v:
Zhongguo linchuang yanjiu, Vol 37, Iss 9, Pp 1374 -1378,1385 (2024)
Objective To analyze their molecular characteristics of microsatellite instability (MSI) by sequencing colorectal cancer patients in Sichuan region. Methods Next generation sequencing (NGS) was used to test 14 239 colon cancer patients from 2017 to 2
Externí odkaz:
https://doaj.org/article/2fc902247fa243c5a19a9d340cf1d239
Publikováno v:
Heliyon, Vol 10, Iss 18, Pp e37741- (2024)
Background: Microsatellite stability (MSS) colorectal cancer (CRC) has poor sensitivity to immunotherapy and its underlying mechanisms are still unclear. Guanylate binding proteins (GBPs) are a family of GTPase involving innate immune responses by pr
Externí odkaz:
https://doaj.org/article/febb44f523ce4463bdaff03191e8bf60
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 67, Iss 2, Pp 275-281 (2024)
Background: Cribriform comedo-type adenocarcinoma (CCA) was a colon cancer subtype defined in the 2009 World Health Organization (WHO) classification. In the 2018 classification, it was a colon cancer subtype included in the adenocarcinoma, Not other
Externí odkaz:
https://doaj.org/article/e305f8e6f44b43c3b38749803c6a52ff
Autor:
Yibing Bai, Tongzhou Li, Qinshu Wang, Weiqiang You, Haochen Yang, Xintian Xu, Ziyi Li, Yu Zhang, Chengsong Yan, Lei Yang, Jiaqian Qiu, Yuanhua Liu, Shiyang Chen, Dongfang Wang, Binlu Huang, Kexin Liu, Bao- Liang Song, Zhuozhong Wang, Kang Li, Xin Liu, Guangchuan Wang, Weiwei Yang, Jianfeng Chen, Pei Hao, Zemin Zhang, Zhigang Wang, Zheng-Jiang Zhu, Chenqi Xu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 334-360 (2024)
Abstract Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC). It is therefore important to study tu
Externí odkaz:
https://doaj.org/article/a0b9d1b7b5d2433d90da1229130e43db
Publikováno v:
Опухоли женской репродуктивной системы, Vol 19, Iss 4, Pp 132-139 (2024)
Despite the existing standard treatments for endometrial cancer, the prognosis for these patients remained poor until recently. None of currently available cytostatics ensured long-term disease control and long-term survival of patients receiving sta
Externí odkaz:
https://doaj.org/article/60d0ae2c4915459c9ed72ec7254d4b57
Autor:
Hamed Hosseinalizadeh, Qusay Mohammed Hussain, Zahra Poshtchaman, Muhammad Ahsan, Ali H. Amin, Soroush Naghavi, Mahmood Khaksary Mahabady
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Keratin 7 (KRT7), also known as cytokeratin-7 (CK-7) or K7, constitutes the principal constituent of the intermediate filament cytoskeleton and is primarily expressed in the simple epithelia lining the cavities of the internal organs, glandular ducts
Externí odkaz:
https://doaj.org/article/7655cf7dec0143b9b7cee8edd87f9a14