Zobrazeno 1 - 10
of 670
pro vyhledávání: '"microsatellite instability (msi)"'
Autor:
Kaname Miyashita, Seijiro Shioi, Tatsuhiro Kajitani, Yumiko Koi, Mototsugu Shimokawa, Akitaka Makiyama, Shinya Oda, Taito Esaki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Microsatellite instability (MSI) is now widely used as an indispensable biomarker. However, the relationship between MSI-H (high) and defective DNA mismatch repair (MMR) is not as straightforward as has been expected. Genome-edited cells car
Externí odkaz:
https://doaj.org/article/0cfc9a4391194efab3c41befb1974e3c
Publikováno v:
Waike lilun yu shijian, Vol 29, Iss 02, Pp 148-155 (2024)
Objective To investigate the consistency between mismatch repair proyeins expressions detected by immunohistochemistry (IHC) and microsatellite instability(MSI) identified by next-generation sequencing (NGS), and evaluate the correlation of these res
Externí odkaz:
https://doaj.org/article/72325ad2c77c44d788a0089fbb238481
Publikováno v:
Frontiers in Surgery, Vol 11 (2024)
BackgroundClinical guidelines suggest screening of colorectal cancer (CRC) for microsatellite instability (MSI). However, microsatellite instability—high (MSI-H) CRC is not rare in older patients. This study aimed to investigate the prevalence of M
Externí odkaz:
https://doaj.org/article/7a549dbbb9d649f89d8e5295af41da81
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101461- (2024)
Colorectal cancer (CRC) is a complicated illness caused by a mix of hereditary and environmental factors. It is one of the most common malignancies worldwide, yet it is also one of the most curable if detected early. There are three types of molecula
Externí odkaz:
https://doaj.org/article/a594d66f3b9a476d986c1012cada4b9c
Autor:
Zinian Jiang, Wentao Xie, Xiaoming Zhou, Wenjun Pan, Sheng Jiang, Xianxiang Zhang, Maoshen Zhang, Zhenqi Zhang, Yun Lu, Dongsheng Wang
Publikováno v:
Insights into Imaging, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Objectives This study aims to develop and validate a virtual biopsy model to predict microsatellite instability (MSI) status in preoperative gastric cancer (GC) patients based on clinical information and the radiomics of deep learning algori
Externí odkaz:
https://doaj.org/article/1bec0852213444c2b32cce6e03b543cf
Akademický článek
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Publikováno v:
Discover Oncology, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Endometrial cancer had a relatively high prevalence of MMR deficiency. MMR-D/MSI-H endometrial cancer patients are suggested to be potential beneficiaries of PD-1/PD-L1 inhibitor therapy. Here, we explored the prognostic value of MSI subtype
Externí odkaz:
https://doaj.org/article/50bd161c75c94e4fa83d44d457c488c0
Publikováno v:
Indian Journal of Pathology and Microbiology, Vol 65, Iss 1, Pp 87-92 (2022)
Context: Approximately 20%–30% of colon cancer cases have a hereditary basis. The genetic defect may involve mismatch repair (MMR) genes, which results in microsatellite instability (MSI). MMR-deficient colorectal cancer may occur due to germline m
Externí odkaz:
https://doaj.org/article/52aa7eb1cfee42d0aafd5cf64b5b21f1
Autor:
Maya Gulubova, Elina Aleksandrova, Yovcho Yovchev, Dimitar Chonov, Petio Chilingirov, Tatyana Vlaykova
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 37, Iss 1 (2023)
Microsatellite instability (MSI) is characterized by a highly immunogenic tumor phenotype and abundant lymphocytic infiltrates. The aim of this study was to investigate the association between four immunohistochemically determined classes of dendriti
Externí odkaz:
https://doaj.org/article/27a0aa5dd8044ea9a61d48ef7c01ac62
Autor:
Richa Malhotra, Vyomesh Javle, Nishtha Tanwar, Pooja Gowda, Linu Varghese, Anju K, Nandhitha Madhusudhan, Nupur Jaiswal, Bhargavi K. S., Manjima Chatterjee, Kumar Prabhash, Peddagangannagari Sreekanthreddy, Kshitij D. Rishi, Hitesh M. Goswami, Vidya H. Veldore
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe concept of personalized medicine in cancer has emerged rapidly with the advancement of genome sequencing and the identification of clinically relevant variants that contribute to disease prognosis and facilitates targeted therapy opti
Externí odkaz:
https://doaj.org/article/52bcbd589f124fa4a8848b986dae61d9