Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours.

Autor: Martin S; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Katainen R; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Taira A; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Välimäki N; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Ristimäki A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Pathology, HUSLAB, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 3, 00290 Helsinki, Finland., Seppälä T; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland.; Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital and TAYS Cancer Centre, Kuntokatu 2, 33520 Tampere, Finland.; Faculty of Medicine and Health Technology, Tampere University, Kalevantie 4, 33100 Tampere, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Renkonen-Sinisalo L; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland., Lepistö A; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Department of Surgery, Helsinki University Central Hospital, Hospital District of Helsinki and Uusimaa, Haartmaninkatu 4, 00290 Helsinki, Finland., Tahkola K; Faculty of Medicine and Health Technology, Tampere University, Kalevantie 4, 33100 Tampere, Finland.; Department of Surgery, Central Finland Health Care District, Keskussairaalantie 19, 40620 Jyväskylä, Finland., Mattila A; Department of Surgery, Central Finland Health Care District, Keskussairaalantie 19, 40620 Jyväskylä, Finland., Koskensalo S; The HUCH Gastrointestinal Clinic, Helsinki University Central Hospital, Stenbäckinkatu 9A, 00029 Helsinki, Finland., Mecklin JP; Department of Education and Research, The Wellbeing Services of Central Finland, Hoitajatie 1, 40620 Jyväskylä, Finland.; Department of Sport and Health Sciences, University of Jyväskylä, Seminaarinkatu 15, 40014 Jyväskylä, Finland., Rajamäki K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Palin K; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland., Aaltonen LA; Medicum/Department of Medical and Clinical Genetics, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.; iCAN Digital Precision Cancer Medicine Flagship, University of Helsinki, Haartmaninkatu 8, 00014 Helsinki, Finland.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2024 Nov 05; Vol. 33 (21), pp. 1858-1872.

Dysfunctional tumor-infiltrating Vδ1 + T lymphocytes in microsatellite-stable colorectal cancer.

Autor: Stary V; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria. victoria.stary@meduniwien.ac.at.; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria. victoria.stary@meduniwien.ac.at., Pandey RV; Medical University of Vienna, Department of Dermatology, Vienna, Austria., List J; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Kleissl L; Medical University of Vienna, Department of Dermatology, Vienna, Austria., Deckert F; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Kabiljo J; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Laengle J; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Gerakopoulos V; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Oehler R; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Watzke L; Medical University of Vienna, Department of Pathology, Vienna, Austria., Farlik M; Medical University of Vienna, Department of Dermatology, Vienna, Austria., Lukowski SW; Department of Human Cancer Immunology, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria., Vogt AB; Department of Human Cancer Immunology, Boehringer Ingelheim RCV GmBH & Co KG., Dr. Boehringer Gasse 5-11, 1120, Vienna, Austria., Stary G; Medical University of Vienna, Department of Dermatology, Vienna, Austria.; CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria., Stockinger H; Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute for Hygiene and Applied Immunology, Vienna, Austria., Bergmann M; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria., Pilat N; Medical University of Vienna, Department of General Surgery, Division of Visceral Surgery, Comprehensive Cancer Center, Vienna, Austria.; Medical University of Vienna, Department of Cardiac Surgery, Vienna, Austria.; Medical University of Vienna, Center for Biomedical Research and Translational Surgery, Vienna, Austria.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 13; Vol. 15 (1), pp. 6949. Date of Electronic Publication: 2024 Aug 13.

Rethinking colorectal cancer prognosis: beyond microsatellite status.

Autor: Fenocchio E; Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Turin 10060, Italy. Electronic address: elisabetta.fenocchio@ircc.it.

Publikováno v: The lancet. Gastroenterology & hepatology [Lancet Gastroenterol Hepatol] 2024 Jul; Vol. 9 (7), pp. 585-586. Date of Electronic Publication: 2024 May 09.

Reply to "Mismatch repair and microsatellite instability-Recommendation for an optimal test strategy".

Autor: Riedinger CJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Esnakula A; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Haight PJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Suarez AA; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Chen W; Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Gillespie J; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Villacres A; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Chassen A; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Cohn DE; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Goodfellow PJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA., Cosgrove CM; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, James Cancer Hospital, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

Publikováno v: Cancer [Cancer] 2024 May 01; Vol. 130 (9), pp. 1713-1714. Date of Electronic Publication: 2024 Mar 02.

One-instrument, objective microsatellite instability analysis using high-resolution melt.

Autor: Bendixen KK; PentaBase A/S, Odense, Denmark., Forsberg-Pho S; PentaBase A/S, Odense, Denmark., Dazio G; Institute of Pathology, Ente Ospedaliero Cantonale, Locarno, Switzerland., Hansen EE; PentaBase A/S, Odense, Denmark., Eriksen SK; PentaBase A/S, Odense, Denmark., Epistolio S; Institute of Pathology, Ente Ospedaliero Cantonale, Locarno, Switzerland., Merlo E; Institute of Pathology, Ente Ospedaliero Cantonale, Locarno, Switzerland., Boldorini R; Unit of Pathology, Department of Health Sciences, University of Eastern Piedmont, Novara, Italy., Venesio T; Candiolo Cancer Institute, Fondazione del Piemonte per l'Oncologia, Candiolo, Italy., Movilia A; Hospital of Legnano, SS Biologia Molecolare, UO Anatomia Patologica, Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano, Legnano, Italy., Caprera C; Laboratory of Molecular Oncology and Predictive Medicine, Pathology Unit, Azienda Ospedaliera Santa Maria di Terni, Terni, Italy., Arnspang EC; Department of Green Technology, Faculty of Engineering, University of Southern Denmark, Odense, Denmark., Børgesen M; PentaBase A/S, Odense, Denmark., Christensen UB; PentaBase A/S, Odense, Denmark., Frattini M; Institute of Pathology, Ente Ospedaliero Cantonale, Locarno, Switzerland., Petersen RK; PentaBase A/S, Odense, Denmark.

Publikováno v: PloS one [PLoS One] 2024 Apr 25; Vol. 19 (4), pp. e0302274. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024).