Zobrazeno 1 - 10
of 861
pro vyhledávání: '"microglia polarization"'
Autor:
Lingui Gu, Hualin Chen, Ruxu Geng, Tingyu Liang, Yihao Chen, Zhuo Wang, Liguo Ye, Mingjiang Sun, Qinglei Shi, Gui Wan, Jianbo Chang, Junji Wei, Wenbin Ma, Jiashun Xiao, Xinjie Bao, Renzhi Wang
Publikováno v:
Neurobiology of Disease, Vol 201, Iss , Pp 106695- (2024)
Background: Spontaneous intracerebral hemorrhage (ICH) is associated with alarmingly high rates of disability and mortality, and current therapeutic options are suboptimal. A critical component of ICH pathology is the initiation of a robust inflammat
Externí odkaz:
https://doaj.org/article/8734b0eb82ed47e6a271e3001e9c4c6c
Autor:
Linqiang Huang, Xinping Li, Zhuo Li, Huishan Zhu, Yongli Han, Juhao Zeng, Miaoyun Wen, Hongke Zeng
Publikováno v:
Brain Research Bulletin, Vol 216, Iss , Pp 111055- (2024)
Background: Cerebral ischemia is characterized by its rapid onset and high rates of recurrence, morbidity, and mortality, with blood-brain barrier (BBB) permeability playing a vital role in brain injury. Therefore, it is important to understand the m
Externí odkaz:
https://doaj.org/article/73133984ee7c4143a37a6f6036a50f47
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110967- (2024)
Purpose: Post-stroke cognitive impairment (PSCI) is a common complication of ischemic stroke episodes. Memory impairment is an important component of the poststroke cognitive syndrome. Microglial activation plays a critical role in stroke-induced neu
Externí odkaz:
https://doaj.org/article/22bf06ee674c4626ba79e285883ac91a
Autor:
Jerry Flores, Jiping Tang
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 2, Pp 350-354 (2024)
Germinal matrix hemorrhage is one of the leading causes of morbidity, mortality, and acquired infantile hydrocephalus in preterm infants in the United States, with little progress made in its clinical management. Blood clots have been shown to elicit
Externí odkaz:
https://doaj.org/article/91809e5f62f04e27a909927276e57afd
Autor:
Shiyi Li, Ru Zhang, Anni Wang, Yang Li, Miaomiao Zhang, Jisu Kim, Ying Zhu, Qizheng Wang, Yue Zhang, Ying Wei, Jianxin Wang
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Cerebral ischemia/reperfusion (CI/R) injury is a clinical conundrum during the treatment of ischemic stroke. Cell-derived exosomes (CDE) were proved to be therapeutically effective for CI/R injury. However, production of CDE is time and effo
Externí odkaz:
https://doaj.org/article/cc3768a1df874b9ab5e828a52a7a8a6e
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 29, Iss 8, p 307 (2024)
Background: Spinal cord injury (SCI) is considered a central nervous system (CNS) disorder. Nuclear factor kappa B (NF-κB) regulates inflammatory responses in the CNS and is implicated in SCI pathogenesis. The mechanism(s) through which NF-κB contr
Externí odkaz:
https://doaj.org/article/3d05d50bfda943bca57d2aa0acbeb717
Publikováno v:
Brain and Behavior, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Introduction Demyelination is a key factor in axonal degeneration and neural loss, leading to disability in multiple sclerosis (MS) patients. Transforming growth factor beta activated kinase 1 (TAK1) is a critical molecule involved in immune
Externí odkaz:
https://doaj.org/article/6ef4102393b648d297212680976a65c9
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophage/microglia function as immune defense and homeostatic cells that originate from bone marrow progenitor cells. Macrophage/microglia activation is historically divided into proinflammatory M1 or anti-inflammatory M2 states based on intracellu
Externí odkaz:
https://doaj.org/article/0f184652d4ea4468b1d3ee038079375b
Autor:
Yuanwei Li, Xiaoxiao Xu, Xuan Wu, Jiarui Li, Shiling Chen, Danyang Chen, Gaigai Li, Zhouping Tang
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 632-645 (2025)
Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory react
Externí odkaz:
https://doaj.org/article/436e240cfdd5467c88afd79e0a7bae63
Autor:
Yue Liang, Ling Chen, Yanmei Huang, Lihua Xie, Xueqin Liu, Wenyan Zhou, Wenyu Cao, Zuyao Chen, Xiaolin Zhong
Publikováno v:
Brain Research Bulletin, Vol 206, Iss , Pp 110863- (2024)
Chronic pain can induce not only nociceptive but also depressive emotions. A previous study demonstrated that betaine, a commonly used nutrient supplement, has an anti-nociceptive effect, but whether betaine can alleviate chronic pain-induced depress
Externí odkaz:
https://doaj.org/article/a2874e73b1c7497eb7a0d6391892e4a0