Zobrazeno 1 - 10
of 666
pro vyhledávání: '"microglia/macrophages"'
Autor:
Sabrina Reinehr, Julien Wulf, Janine Theile, Kim K. Schulte, Marcus Peters, Rudolf Fuchshofer, H. Burkhard Dick, Stephanie C. Joachim
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe neurodegenerative processes leading to glaucoma are complex. In addition to elevated intraocular pressure (IOP), an involvement of immunological mechanisms is most likely. In the new multifactorial glaucoma model, a combination of high
Externí odkaz:
https://doaj.org/article/799de27d974245298b0db025ebd09068
Autor:
Yuluo Rong, Zhuanghui Wang, Pengyu Tang, Jiaxing Wang, Chengyue Ji, Jie Chang, Yufeng Zhu, Wu Ye, Jianling Bai, Wei Liu, Guoyong Yin, Lipeng Yu, Xuhui Zhou, Weihua Cai
Publikováno v:
Bioactive Materials, Vol 23, Iss , Pp 328-342 (2023)
Spinal cord injury (SCI) is a severe disease of the nervous system that causes irreparable damage and loss of function, for which no effective treatments are available to date. Engineered extracellular vesicles (EVs) carrying therapeutic molecules ho
Externí odkaz:
https://doaj.org/article/fbfdf5bc8d454119bc9b1cd2763f9c7a
Autor:
Lin Li, Weifeng Jiang, Baojian Yu, Huiqi Liang, Shihui Mao, Xiaowei Hu, Yan Feng, Jiadong Xu, Lisheng Chu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115653- (2023)
The modulation of microglial polarization from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype shows promise as a therapeutic strategy for ischemic stroke. Quercetin, a natural flavonoid abundant in various plants, possesses anti-inflam
Externí odkaz:
https://doaj.org/article/2892a161180a448aaa35a3393f9f649e
Autor:
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored. In this study, we characterized the molecular mechanisms of how vitamin D signa
Externí odkaz:
https://doaj.org/article/04ff7d2fca2b4b40b8846293957ecf9d
Autor:
Xuhui Ge, Zheng Zhou, Siting Yang, Wu Ye, Zhuanghui Wang, Jiaxing Wang, Chenyu Xiao, Min Cui, Jiawen Zhou, Yufeng Zhu, Rixiao Wang, Yu Gao, Haofan Wang, Pengyu Tang, Xuhui Zhou, Ce Wang, Weihua Cai
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Spinal cord injury (SCI) can result in irreversible sensory and motor disability with no effective treatment currently. After SCI, infiltrated macrophages accumulate in epicenter through destructed blood-spinal cord barrier (BSCB). Further,
Externí odkaz:
https://doaj.org/article/59e9972aa53747989ae6e8429e14f1e3
Publikováno v:
Biomaterials Research, Vol 26, Iss 1, Pp 1-24 (2022)
Abstract Background Despite limited efficiency, modulation of microglia/macrophages has shown to attenuate neuroinflammation after intracerebral hemorrhage (ICH). In this context, we evaluated the efficacy of modified exosomal signal regulatory prote
Externí odkaz:
https://doaj.org/article/2e3771b1fe7c4298bb4642e48f42eee0
Autor:
Casper J. Pachocki, Elly M. Hol
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only radiation therapy provides marginal survival benefit; howeve
Externí odkaz:
https://doaj.org/article/234df7400cc647c8abd0b33c1adfa638
Autor:
Yolanda Pires‐Afonso, Arnaud Muller, Kamil Grzyb, Anaïs Oudin, Yahaya A. Yabo, Carole Sousa, Andrea Scafidi, Aurélie Poli, Antonio Cosma, Rashi Halder, Djalil Coowar, Anna Golebiewska, Alexander Skupin, Simone P. Niclou, Alessandro Michelucci
Publikováno v:
Molecular Oncology, Vol 16, Iss 17, Pp 3167-3191 (2022)
In glioblastoma (GBM), tumour‐associated microglia/macrophages (TAMs) represent the major cell type of the stromal compartment and contribute to tumour immune escape mechanisms. Thus, targeting TAMs is emerging as a promising strategy for immunothe
Externí odkaz:
https://doaj.org/article/7cce8814107e4c53bb9804c062f2799f
Autor:
Zhanna Oliynyk, Mariia Rudyk, Taisa Dovbynchuk, Nataliia Dzubenko, Ganna Tolstanova, Larysa Skivka
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 30, Iss , Pp 100616- (2023)
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting more than 1% of aged people. PD, which was previously identified as movement disorder, now is recognized as a multi-factorial systemic disease with important path
Externí odkaz:
https://doaj.org/article/53bc435098f0481998e3ccf8913d4b91
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/ca81ea9c29c5415896542df27f86c6b0