Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

Autor: Donna M. Wilcock, Cynthia A. Lemere, Elizabeth Head, Ira T. Lott

Publikováno v: Head, Elizabeth; Lott, Ira T; Wilcock, Donna M; & Lemere, Cynthia A. (2016). Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology.. Current Alzheimer research, 13(1), 18-29. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/20c4c1wp

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to play a critical role in the development of AD neuropathology. The overexpression of the gene for the amyloid precursor protein (APP), on chromosome 21, leads to e

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http://www.escholarship.org/uc/item/20c4c1wp