Zobrazeno 1 - 10
of 224
pro vyhledávání: '"microProteins"'
Microprotein-encoding RNA regulation in cells treated with pro-inflammatory and pro-fibrotic stimuli
Autor:
Victor J. Pai, Calvin J. Lau, Almudena Garcia-Ruiz, Cynthia Donaldson, Joan M. Vaughan, Brendan Miller, Eduardo V. De Souza, Antonio M. Pinto, Jolene Diedrich, Narender R. Gavva, Shan Yu, Christopher DeBoever, Shane R. Horman, Alan Saghatelian
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Background Recent analysis of the human proteome via proteogenomics and ribosome profiling of the transcriptome revealed the existence of thousands of previously unannotated microprotein-coding small open reading frames (smORFs). Most functi
Externí odkaz:
https://doaj.org/article/f592bdfb616c471e85494c623631515a
Autor:
Shining Loo, Antony Kam, Bamaprasad Dutta, Xiaohong Zhang, Nan Feng, Siu Kwan Sze, Chuan-Fa Liu, Xiaoliang Wang, James P. Tam
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 653-666 (2024)
Stress and illness connection is complex and involves multiple physiological systems. Panax ginsengs, reputed for their broad-spectrum “cure-all” effect, are widely prescribed to treat stress and related illnesses. However, the identity of ginsen
Externí odkaz:
https://doaj.org/article/2d32b34c63674ff9b48d2c7783da2f7e
Autor:
Clémence Guillon, Carole Pichereaux, Ikrame Lazar, Karima Chaoui, Emmanuelle Mouton-Barbosa, Mehdi Liauzun, Edith Gourbeyre, Pinar Altiner, David Bouyssié, Alexandre Stella, Odile Burlet-Schiltz, Serge Plaza, Yvan Martineau, Bertrand Fabre
Publikováno v:
Cells, Vol 13, Iss 23, p 1966 (2024)
The identification of small proteins and proteins produced from unannotated open reading frames (called alternative proteins or AltProts) has changed our vision of the proteome and has attracted more and more attention from the scientific community.
Externí odkaz:
https://doaj.org/article/e6b0dd9b8b7d47b6a03124e57c0cdb72
Publikováno v:
Cells, Vol 13, Iss 19, p 1645 (2024)
Recently developed experimental and computational approaches to identify putative coding small ORFs (smORFs) in genomes have revealed thousands of smORFs localized within coding and non-coding RNAs. They can be translated into smORF peptides or micro
Externí odkaz:
https://doaj.org/article/1151405a033645f2863c662e983590f3
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Short open reading frames (sORF) have the potential to encode small proteins, sORF-encoded peptides (SEP), which are less than or equal to 100 amino acids in length. These SEP have been associated with various physiological processes and are
Externí odkaz:
https://doaj.org/article/dd2bcf8cfda0427895d21b24e7e91908
Autor:
Deniz Üresin, Dennis J. Pyper, Andreas Borst, Lydia Hadjeras, Rick Gelhausen, Rolf Backofen, Cynthia Sharma, Harald Schwalbe, Jörg Soppa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
It is increasingly recognized that very small proteins (μ-proteins) are ubiquitously found in all species of the three domains of life, and that they fulfill important functions. The halophilic archaeon Haloferax volcanii contains 282 μ-proteins of
Externí odkaz:
https://doaj.org/article/5e3c294724f24213b6494198bc242a45
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Akademický článek
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Autor:
Alyssa Zi-Xin Leong, Pey Yee Lee, M. Aiman Mohtar, Saiful Effendi Syafruddin, Yuh-Fen Pung, Teck Yew Low
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-15 (2022)
Abstract A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as meaningless noise, sORFs were
Externí odkaz:
https://doaj.org/article/2fc1cfb9a2484c9089e323bf140597ed