Zobrazeno 1 - 10
of 346
pro vyhledávání: '"miRNA therapeutics"'
Autor:
Katia Grillone, Giulio Caridà, Francesco Luciano, Alessia Cordua, Maria Teresa Di Martino, Pierosandro Tagliaferri, Pierfrancesco Tassone
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Targeting non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has recently emerged as a promising strategy for treating malignancies and other diseases. In recent years, the development of ncRNA-based t
Externí odkaz:
https://doaj.org/article/0c52af7cc6fc4a4093b34945946ae272
Autor:
Fereshteh Rahdan, Alihossein Saberi, Neda Saraygord-Afshari, Morteza Hadizadeh, Tahura Fayeghi, Elham Ghanbari, Hassan Dianat-Moghadam, Effat Alizadeh
Publikováno v:
Heliyon, Vol 10, Iss 20, Pp e39489- (2024)
Hepatocellular carcinoma (HCC) poses a significant global health challenge, necessitating innovative therapeutic strategies. MicroRNAs (miRNAs) have emerged as pivotal regulators of HCC pathogenesis, influencing key processes such as self-renewal, an
Externí odkaz:
https://doaj.org/article/785e596ace204e49a2fe39876b40b771
Autor:
Kontham Kulangara Varsha, Xiaoming Yang, Alkeiver S. Cannon, Yin Zhong, Mitzi Nagarkatti, Prakash Nagarkatti
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile arthritis, accompanied by cytokine storm and hemophagocytosis. In addition, COVID-19–related hyperinflammation shares clinical features of MAS. Mechanisms
Externí odkaz:
https://doaj.org/article/dee9da17dd404f94bc0e8504bbc06ec1
Publikováno v:
Biologics: Targets & Therapy, Vol Volume 17, Pp 113-128 (2023)
Zhiying Zhang, Rui Zhang, Donghai Li Inner Mongolia Medical University, Department of Thyroid Breast Surgery, Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia, 010050, People’s Republic of ChinaCorrespondence: Rui Zhang, Inn
Externí odkaz:
https://doaj.org/article/ebcbf91beb9e4b46aa8ddd68a78c041e
Autor:
Mushtaq Gohar, Hasani Ibrahim W., Al-Daoud Fouad, Unnisa Aziz, Mutair Yahya A., Kabba Samer, Alkanash Yaser
Publikováno v:
Türk Biyokimya Dergisi, Vol 48, Iss 5, Pp 446-458 (2023)
MicroRNAs (miRNAs) are small non-coding molecules that play a pivotal part in brain development and the processes of establishment and maintenance of dendrites and neurite outgrowth by modulating gene expression. Dysregulation of miRNAs has been link
Externí odkaz:
https://doaj.org/article/1ccc7910cc2f46d5aee02248714e2c39
Autor:
Pierfrancesco Tassone, Maria Teresa Di Martino, Mariamena Arbitrio, Lucia Fiorillo, Nicoletta Staropoli, Domenico Ciliberto, Alessia Cordua, Francesca Scionti, Bernardo Bertucci, Angela Salvino, Mariangela Lopreiato, Fredrik Thunarf, Onofrio Cuomo, Maria Cristina Zito, Maria Rosanna De Fina, Amelia Brescia, Simona Gualtieri, Caterina Riillo, Francesco Manti, Daniele Caracciolo, Vito Barbieri, Eugenio Donato Di Paola, Adele Emanuela Di Francesco, Pierosandro Tagliaferri
Publikováno v:
Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-12 (2023)
Abstract Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated miR-221, demonstrated anti-tumor activity against human xenografts
Externí odkaz:
https://doaj.org/article/4d9a753abc2e49c2bbde30064f04d177
Autor:
Lalit Kaurani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2866 (2024)
Depression is a major contributor to the overall global burden of disease. The discovery of biomarkers for diagnosis or prediction of treatment responses and as therapeutic agents is a current priority. Previous studies have demonstrated the importan
Externí odkaz:
https://doaj.org/article/8a3ca78ddfd64633aad374294b3011af
Publikováno v:
Biomedical Papers, Vol 166, Iss 4, Pp 359-368 (2022)
A number of microRNAs are involved in the pathophysiological events associated with heart disease. In this review, we discuss miR-21, miR-1, miR-23a, miR-142-5p, miR-126, miR-29, miR-195, and miR-499 because they are most often mentioned as important
Externí odkaz:
https://doaj.org/article/3f09e765e1a54662addb6fbf442d95ac
Autor:
Neha Datta, Charlotte Johnson, Dina Kao, Pratik Gurnani, Cameron Alexander, Christos Polytarchou, Tanya M. Monaghan
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106870- (2023)
An emerging but less explored shared pathophysiology across microbiota-gut-brain axis disorders is aberrant miRNA expression, which may represent novel therapeutic targets. miRNAs are small, endogenous non-coding RNAs that are important transcription
Externí odkaz:
https://doaj.org/article/dbe53f00f7be4e4a83fb34164729e9b6
Autor:
Wen (Jess) Li, Yunfei Wang, Xiaozhuo Liu, Shan Wu, Moyi Wang, Steven G. Turowski, Joseph A. Spernyak, Amanda Tracz, Ahmed M. Abdelaal, Kasireddy Sudarshan, Igor Puzanov, Gurkamal Chatta, Andrea L. Kasinski, Dean G. Tang
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2123 (2024)
Prostate cancer (PCa) remains a common cancer with high mortality in men due to its heterogeneity and the emergence of drug resistance. A critical factor contributing to its lethality is the presence of prostate cancer stem cells (PCSCs), which can s
Externí odkaz:
https://doaj.org/article/e53665e2fdbf4db98c8a6545b64a0204