Zobrazeno 1 - 10
of 134
pro vyhledávání: '"miRISC"'
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 151-161 (2024)
MicroRNAs (miRNAs) are small noncoding RNAs (ncRNAs) that play their roles in the regulation of physiological and pathological processes. Originally, it was assumed that miRNAs only modulate gene expression posttranscriptionally in the cytoplasm by i
Externí odkaz:
https://doaj.org/article/d41f1a26e7ef479b95c914c618480477
Autor:
Xian Zhao, Yingting Cao, Runhui Lu, Zihan Zhou, Caihu Huang, Lian Li, Jiayi Huang, Ran Chen, Yanli Wang, Jian Huang, Jinke Cheng, Junke Zheng, Yujie Fu, Jianxiu Yu
Publikováno v:
Advanced Science, Vol 11, Iss 15, Pp n/a-n/a (2024)
Abstract Non‐small‐cell lung cancer (NSCLC) is a highly lethal tumor that often develops resistance to targeted therapy. It is shown that Tank‐binding kinase 1 (TBK1) phosphorylates AGO2 at S417 (pS417‐AGO2), which promotes NSCLC progression
Externí odkaz:
https://doaj.org/article/b52bb434766f4888b2363bcc83ae8ad5
Autor:
Yun-Long Wang, Li-Li Feng, Jie Shi, Wan-Ying Chen, Shu-Ying Bie, Shao-Mei Bai, Guang-Dong Zeng, Rui-Zhi Wang, Jian Zheng, Xiang-Bo Wan, Xin-Juan Fan
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTNoncoding RNAs have been found to play important roles in DNA damage repair, whereas the participation of circRNA remains undisclosed. Here, we characterized ciRS-7, a circRNA containing over 70 putative miR-7-binding sites, as an enhancer of
Externí odkaz:
https://doaj.org/article/bee520bfbc00401088b402ce11f3625a
Akademický článek
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Autor:
Courtney F. Jungers, Sergej Djuranovic
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Gene expression is regulated at multiple levels in eukaryotic cells. Regulation at the post-transcriptional level is modulated by various trans-acting factors that bind to specific sequences in the messenger RNA (mRNA). The binding of different trans
Externí odkaz:
https://doaj.org/article/dd6d7484d15f42918157d21719945f15
Autor:
Pavan Kumar Kakumani
Publikováno v:
Translational Oncology, Vol 21, Iss , Pp 101434- (2022)
MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets
Externí odkaz:
https://doaj.org/article/3ca59d3b785348008ff63c27f2bccaa7
Autor:
Gaspare La Rocca, Bryan King, Bing Shui, Xiaoyi Li, Minsi Zhang, Kemal M Akat, Paul Ogrodowski, Chiara Mastroleo, Kevin Chen, Vincenzo Cavalieri, Yilun Ma, Viviana Anelli, Doron Betel, Joana Vidigal, Thomas Tuschl, Gunter Meister, Craig B Thompson, Tullia Lindsten, Kevin Haigis, Andrea Ventura
Publikováno v:
eLife, Vol 10 (2021)
Although virtually all gene networks are predicted to be controlled by miRNAs, the contribution of this important layer of gene regulation to tissue homeostasis in adult animals remains unclear. Gain and loss-of-function experiments have provided key
Externí odkaz:
https://doaj.org/article/caa7c7e535be45199b348ce0b4f5658f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
MicroRNAs (miRNAs) are small non-coding RNAs which post-transcriptionally suppress target mRNAs expression and/or translation to modulate pathophyological processes. Expression and function of miRNAs are fine-tuned by a conserved biogenesis machinery
Externí odkaz:
https://doaj.org/article/570dde2c23514294900e23939625e293
Akademický článek
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Akademický článek
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