Zobrazeno 1 - 10
of 368
pro vyhledávání: '"miR-33"'
Akademický článek
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Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-14 (2021)
Abstract miRNAs have emerged as critical regulators of nearly all biologic processes and important therapeutic targets for numerous diseases. However, despite the tremendous progress that has been made in this field, many misconceptions remain among
Externí odkaz:
https://doaj.org/article/f9de2e4064ff4f6b9075aa00a4d61d3c
Autor:
Chunyan Peng, Pan Lei, Xiandong Li, Huaqiang Xie, Xiaowen Yang, Tao Zhang, Zheng Cao, Jicai Zhang
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background Sterol regulatory-element binding proteins (SREBPs) and mir-33 (miR-33a, miR-33b), which are encoded by the introns of SREBPs, are key factors in the lipid metabolism pathway. SREBPs mRNA in circulating leucocyte and carotid plaqu
Externí odkaz:
https://doaj.org/article/828d1cbcac9044d4907f604d1acd32b3
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Yaoye Tao, Shengjun Xu, Jianguo Wang, Li Xu, Chenzhi Zhang, Kangchen Chen, Zhengxing Lian, Junbin Zhou, Haiyang Xie, Shusen Zheng, Xiao Xu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Lipid metabolic disorders have become a major global public health concern. Fatty liver and dyslipidemia are major manifestations of these disorders. Recently, MicroRNA-33 (miR-33), a post-transcriptional regulator of genes involved in cholesterol ef
Externí odkaz:
https://doaj.org/article/2e7f350126994a378c92b7ce986a0608
Autor:
Yan Sun, Dai Zhang, Xiaoli Liu, Xuesong Li, Fang Liu, Yi Yu, Shuo Jia, Yujie Zhou, Yingxin Zhao
Publikováno v:
Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 1995-2010 (2018)
Background/Aims: Endoplasmic reticulum (ER) stress is an important event in atherosclerosis. Recent studies have shown that ER stress deregulates cholesterol metabolism via multiple pathways. This study aimed to determine the relationship between ER
Externí odkaz:
https://doaj.org/article/5e62e8741f854582883cf74b3c77e168
Autor:
Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Publikováno v:
Cell Reports, Vol 22, Iss 8, Pp 2133-2145 (2018)
Summary: While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovas
Externí odkaz:
https://doaj.org/article/e344e7cdc5634e7db68d175d5c1581a0
Publikováno v:
ARYA Atherosclerosis, Vol 13, Iss 6, Pp 257-263 (2017)
BACKGROUND: microRNAs play pivotal roles in metabolism and other aspects of cell biology. microRNA-33 and liver X receptor (LXR) affect lipid metabolism and cholesterol trafficking. In this study, we evaluated effects of co-administration of miR-33 i
Externí odkaz:
https://doaj.org/article/9fd38748d03c497eb4263a46fa489d14
Autor:
Silvia Cetrullo, Stefania D’Adamo, Veronica Panichi, Rosa Maria Borzì, Carla Pignatti, Flavio Flamigni
Publikováno v:
Cells, Vol 9, Iss 3, p 537 (2020)
While high levels of saturated fatty acids are associated with impairment of cardiovascular functions, n-3 polyunsaturated fatty acids (PUFAs) have been shown to exert protective effects. However the molecular mechanisms underlying this evidence are
Externí odkaz:
https://doaj.org/article/13bd2dbaf2074b669b4247a316174547