Výsledky vyhledávání - "metronomic therapy"

Akademický článek

A real-world study on the clinicopathological profile, treatment outcomes and health-related quality of life, anxiety and depression among patients with desmoid tumor at two tertiary care centers in India

Autor: Ghazal Tansir, Aparna Sharma, Bivas Biswas, Suryadev Narayan Sah, Somnath Roy, S. V. S. Deo, Sandeep Agarwala, Shah Alam Khan, Sameer Bakhshi, Deepam Pushpam

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

BackgroundThe medical management of DT comprises tyrosine kinase inhibitors (TKIs), hormonal agents, anti-inflammatory drugs with the recently approved gamma secretase inhibitor nirogacestat being the current standard of care. Real-world data on evol

Externí odkaz: https://doaj.org/article/e35a9dd3bdca44778e32f4181355d3be

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Metronomic cyclophosphamide and metformin inhibited tumor growth and repopulated tumor-infiltrating lymphocytes in an experimental carcinoma model

Autor: Heba Mohamed Zaki, Khadiga Mohamed Ali, Mona Younis Youssef Abd Allah, Amoura Mohamed Abouelnaga, Mohamed Elsaid Abdraboh, Osama Hussein

Publikováno v: BMC Research Notes, Vol 17, Iss 1, Pp 1-6 (2024)

Abstract Metformin is a widely used antidiabetic biguanide. Retrospective data demonstrated the association of metformin use with survival benefit in multiple tumor types. Interest in repurposing metformin to treat cancer has not been translated into

Externí odkaz: https://doaj.org/article/aab24b9d0336470880422ef8b22cb1e4

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Akademický článek

Differential Expression of NOTCH-1 and Its Molecular Targets in Response to Metronomic Followed by Conventional Therapy in a Patient with Advanced Triple-Negative Breast Cancer

Autor: Alice Ilari, Viola Cogliati, Noorhan Sherif, Emanuela Grassilli, Daniele Ramazzotti, Nicoletta Cordani, Giorgio Cazzaniga, Camillo Di Bella, Marialuisa Lavitrano, Marina Elena Cazzaniga, Maria Grazia Cerrito

Publikováno v: Biomedicines, Vol 12, Iss 2, p 272 (2024)

A group of 27 patients diagnosed with metastatic triple-negative breast cancer (mTNBC) was randomly distributed into two groups and underwent different lines of metronomic treatment (mCHT). The former group (N 14) received first-line mCHT and showed

Externí odkaz: https://doaj.org/article/b98e10cb1aa94412a8a4253e60045bb6

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Akademický článek

Striking balance between expedited review and expecting efficacious anticancer drug and biologics: An ongoing challenge

Autor: Krishnan Vengadaragava Chary, Anita Ramesh

Publikováno v: Perspectives in Clinical Research, Vol 8, Iss 4, Pp 176-179 (2017)

Objective: The objective of this study is to assess the postmarketing status: Efficacy and safety drugs and biologics related with cancer approved under expedited review. Methods: This observational, analytical study was carried between January and A

Externí odkaz: https://doaj.org/article/86ee1ddc03f84548b7c022b02b57c415

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Development of a population pharmacokinetic/pharmacodynamic model for various oral paclitaxel formulations co-administered with ritonavir and thrombospondin-1 based on data from early phase clinical studies

Autor: Maarten van Eijk, Huixin Yu, Emilia Sawicki, Vincent A. de Weger, Bastiaan Nuijen, Thomas P. C. Dorlo, Jos H. Beijnen, Alwin D. R. Huitema

Publikováno v: Cancer Chemotherapy and Pharmacology. 90:71-82

Purpose Orally administered paclitaxel offers increased patient convenience while providing a method to prolong exposure without long continuous, or repeated, intravenous infusions. The oral bioavailability of paclitaxel is improved through co-admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38da342168d4b4eb33c26c4a7ade060
https://doi.org/10.1007/s00280-022-04445-z

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Role of metronomic therapy for advanced oral cancers and predictors of response: Multi‐institutional feasibility study

Autor: Ashutosh Mishra, Mahesh Sultania, Madhabananda Kar, Atul Sharma, Mohammed Imaduddin, Dillip Kumar Muduly, Saroj Kumar Das Majumdar, Amit Kumar Adhya, Sunil Kumar, Dilip Kumar Parida, Suryanarayana S.V. Deo

Publikováno v: Head & Neck. 44:104-112

Background In an era of targeted therapies, patients with cancer in resource-constraint countries continue to struggle to find affordable care. Methods The present study is a multicenter prospective single-arm study. Patients with expected delay in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a70676a463c53329e1380f8e737bede
https://doi.org/10.1002/hed.26904

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