Zobrazeno 1 - 10
of 2 330
pro vyhledávání: '"methylation analysis"'
Autor:
Junya Yamaguchi, Fumiharu Ohka, Masafumi Seki, Kazuya Motomura, Shoichi Deguchi, Yoshiki Shiba, Yuka Okumura, Yuji Kibe, Hiroki Shimizu, Sachi Maeda, Yuhei Takido, Ryo Yamamoto, Akihiro Nakamura, Kennosuke Karube, Ryuta Saito
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-7 (2024)
Abstract Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma and oligodendroglioma. However, the significance of IDH mutation in tumor maintenance and malignant transformation has n
Externí odkaz:
https://doaj.org/article/f9f5ded7c6c5412cb0f008ce4aa78f77
Comprehensive molecular and clinical findings in 29 patients with multi-locus imprinting disturbance
Autor:
Tatsuki Urakawa, Hidenobu Soejima, Kaori Yamoto, Kaori Hara-Isono, Akie Nakamura, Sayaka Kawashima, Hiromune Narusawa, Rika Kosaki, Yutaka Nishimura, Kazuki Yamazawa, Tetsuo Hattori, Yukako Muramatsu, Takanobu Inoue, Keiko Matsubara, Maki Fukami, Shinji Saitoh, Tsutomu Ogata, Masayo Kagami
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Multi-locus imprinting disturbance (MLID) with methylation defects in various differentially methylated regions (DMRs) has recently been identified in approximately 150 cases with imprinting disorders (IDs), and deleterious varian
Externí odkaz:
https://doaj.org/article/6b5bfe603f204369b891655890db9f4d
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Colorectal cancer is one of the most common cancers worldwide. DNA methylation sites may serve as a new gene signature for colorectal cancer diagnosis. The search for representative DNA methylation sites is urgently needed. This s
Externí odkaz:
https://doaj.org/article/11aabf9095484a33ba1fcc60a8bff9e5
Autor:
Tian Wang, Yu-Chun Fan, Lin-Li Zhang, Min-Yu Nong, Guang-Fei Zheng, Wan-Shuo Wei, Li-He Jiang
Publikováno v:
Journal of Holistic Integrative Pharmacy, Vol 5, Iss 2, Pp 90-102 (2024)
Objective: Currently, the incidence of hepatocellular carcinoma remains high, and the prognosis of patients is poor. Prognostic biomarkers are still worth exploring. Methods: Based on The Cancer Genome Atlas (TCGA) database, the differentially expres
Externí odkaz:
https://doaj.org/article/ac1906404e5b4161957991ae7e1a143e
Autor:
Yuki Tanaka, Yuri Nakanishi, Erina Furuhata, Ken-ichi Nakada, Rino Maruyama, Harukazu Suzuki, Takahiro Suzuki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized by thrombocytopenia, platelet dysfunction, and a predisposition
Externí odkaz:
https://doaj.org/article/a8d345d8c8054bdaa2f92711c813a6b2
Akademický článek
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Autor:
Barinder Bajwa, Xiaohui Xing, Spencer C. Serin, Maria Hayes, Stephanie A. Terry, Robert J. Gruninger, D. Wade Abbott
Publikováno v:
Marine Drugs, Vol 22, Iss 10, p 464 (2024)
This study introduces a novel approach to analyze glycosidic linkages in unfractionated polysaccharides from alcohol-insoluble residues (AIRs) of five brown seaweed species. GC-MS analysis of partially methylated alditol acetates (PMAAs) enables moni
Externí odkaz:
https://doaj.org/article/5b88a2c5d8a743fb8363d88e99b7469d
Autor:
Kohei Fukuoka, Jun Kurihara, Tomoko Shofuda, Naoki Kagawa, Kai Yamasaki, Ryo Ando, Joji Ishida, Masayuki Kanamori, Atsufumi Kawamura, Young-Soo Park, Chikako Kiyotani, Takuya Akai, Dai Keino, Yosuke Miyairi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Atsuko Nakazawa, Katsuyoshi Koh, Ryo Nishikawa, Isao Date, Motoo Nagane, Koichi Ichimura, Yonehiro Kanemura
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-8 (2023)
Abstract Background One of the most significant challenges in patients with medulloblastoma is reducing the dose of craniospinal irradiation (CSI) to minimize neurological sequelae in survivors. Molecular characterization of patients receiving lower
Externí odkaz:
https://doaj.org/article/b7ca166b3bb24b038b8aa6431c3ba065
Autor:
Ewelina Pośpiech, Aleksandra Pisarek, Joanna Rudnicka, Rezvan Noroozi, Michał Boroń, Aleksander Masny, Bożena Wysocka, Kamila Migacz-Gruszka, Dagmara Lisman, Paulina Pruszkowska-Przybylska, Magdalena Kobus, Maria Szargut, Joanna Dowejko, Kamila Stanisz, Julia Zacharczuk, Piotr Zieliński, Aneta Sitek, Andrzej Ossowski, Magdalena Spólnicka, Wojciech Branicki
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background DNA methylation analysis has proven to be a powerful tool for age assessment. However, the implementation of epigenetic age prediction in diagnostics or routine forensic casework requires appropriate laboratory methods. In this st
Externí odkaz:
https://doaj.org/article/41ae9f2b68714fcf9f5be3f7a22490df
Autor:
Kimiaki Takagi, Azumi Naruse, Kazutoshi Akita, Yuka Muramatsu-Maekawa, Kota Kawase, Takuya Koie, Masanobu Horie, Arizumi Kikuchi
Publikováno v:
BMC Urology, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract Background DNA methylation in cancer is considered a diagnostic and predictive biomarker. We investigated the usefulness of the methylation status of CALN1 as a biomarker for bladder cancer using methylation-sensitive restriction enzyme (MSR
Externí odkaz:
https://doaj.org/article/bd1c4aa415ed4288bfb66072c3e81bb6