Výsledky vyhledávání - "methyl guanine methyl transferase"

Akademický článek

Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor

Autor: Smrdel Uros, Popovic Mara, Zwitter Matjaz, Bostjancic Emanuela, Zupan Andrej, Kovac Viljem, Glavac Damjan, Bokal Drago, Jerebic Janja

Publikováno v: Radiology and Oncology, Vol 50, Iss 4, Pp 394-401 (2016)

In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly predict long-te

Externí odkaz: https://doaj.org/article/be43555d40db40cbb067515065b5571d

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Long-term survival in glioblastoma: methyl guanine methyl transferase (MGMT) promoter methylation as independent favourable prognostic factor

Autor: Drago Bokal, Viljem Kovac, Emanuela Boštjančič, Uros Smrdel, Andrej Zupan, Damjan Glavač, Janja Jerebic, Mara Popović, Matjaz Zwitter

Publikováno v: Radiology and Oncology, Vol 50, Iss 4, Pp 394-401 (2016)
Radiology and Oncology
Europe PubMed Central

Background In spite of significant improvement after multi-modality treatment, prognosis of most patients with glioblastoma remains poor. Standard clinical prognostic factors (age, gender, extent of surgery and performance status) do not clearly pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3472cb026df7e42545498b052aba5e65
https://doaj.org/article/be43555d40db40cbb067515065b5571d

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Methyl Guanine Methyl Transferase Methylation Status and Epidermal Growth Factor Receptor expression in a cohort of Egyptian glioblastoma patients

Autor: Soheir M. Hamam, Doaa A Abdelmonsif, Iman M. Talaat, Rasha A. Nassra, Bassma M. El Sabaa

Publikováno v: Egyptian Journal of Pathology. 36:282-288

IntroductionGlioblastoma multiforme is the most frequently occurring primary brain tumour with a dismal prognosis. Chemotherapy with an alkylating agent such as Temozolomide (TMZ) confers a significant survival benefit. Genomic data elucidating patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f30c4a67eb62b23183a32c40ab7a39f
https://doi.org/10.1097/01.xej.0000511094.91402.70

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The scrambled story between hyaluronan and glioblastoma

Autor: Silvia E. Hajos, Matías Pibuel, Daniela Poodts, Mariángeles Díaz, Silvina Lompardía

Publikováno v: The Journal of Biological Chemistry

Advances in cancer biology are revealing the importance of the cancer cell microenvironment on tumorigenesis and cancer progression. Hyaluronan (HA), the main glycosaminoglycan in the extracellular matrix, has been associated with the progression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51a668982b77746ddcbc2e12d92d7cd
https://doi.org/10.1016/j.jbc.2021.100549

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Expression of O6 Methyl Guanine Methyl Transferase (Mgmt) in Oral Squamous Cell Carcinoma Patients in Alexandria, Egypt (Smokers and Non-Smokers)

Autor: Ahmed Serag Habib, Sahar M. El-Sheikh, Hend Mohamed Helmy, Taissir A. Omar

Publikováno v: American Journal of Life Sciences. 2:217

Objectives: O6-methylguanine-DNA methyltransferase (MGMT) removes mutagenic, carcinogenic, and cytotoxic adducts from O6-methylguanine in DNA through a direct reversal mechanism. Decreased expression of MGMT has been reported in a variety of human ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::386d00954ce41d0c2736f230fa489880
https://doi.org/10.11648/j.ajls.20140204.15

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Phase I trial of the addition of oral topotecan to standard 5-day temozolomide for malignant gliomas

Autor: Katherine B. Peters, John P. Kirkpatrick, David A. Reardon, Henry S. Friedman, Sarah Woodring, Jennifer Marcello, A. Desjardins, Sridharan Gururangan, James E. Herndon, James J. Vredenburgh

Publikováno v: Journal of Clinical Oncology. 28:2073-2073

2073 Background: Temozolomide is one of the most active agents to treat malignant gliomas. As an alkylating agent, the majority of tumors develop resistance. There are many mechanisms of resistance, including methyl guanine methyl transferase (MGMT),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c21446bd0553cccb10c5de7566b5c97
https://doi.org/10.1200/jco.2010.28.15_suppl.2073

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Detection of hypermethylation in the CpG Islands of the p16INK4A and methyl-guanine methyl-transferase (MGMT) gene promoters in pancreatic adenocarcinoma (PC)

Autor: I. Boukovinas, P. Stravoravdi, T. Toliou, A. Kiziridou, S. Voyatzi, D. Paikos, I. Stergiou

Publikováno v: Journal of Clinical Oncology. 26:14656-14656

14656 Background: Pancreatic cancer consists of an accumulation of genetic and epigenetic alterations. DNA methylation is an important epigenetic mechanism of transcriptional regulation during tumo...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e5b430fb84a11ea3a66958ee98134fd
https://doi.org/10.1200/jco.2008.26.15_suppl.14656

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